NCT00730054已完成1 期
Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
Oslo University Hospital1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2005年2月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Relief of pain(VAS reduction)
研究概览
简要总结
The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.
详细描述
To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- 未提供
研究组 & 干预措施
1
Active Comparator
Clonidine
干预措施: Remifentanil+clonidine (Drug)
2
Active Comparator
Remifentanil
干预措施: Remifentanil+clonidine (Drug)
4
Experimental
Remifentanil+clonidine
干预措施: Remifentanil+clonidine (Drug)
3
Placebo Comparator
Placebo
干预措施: Remifentanil+clonidine (Drug)
结局指标
主要结局
Relief of pain(VAS reduction)
时间窗: Experimental
次要结局
- Reduction in Minute ventilation(Experimental)
- Reduction in CO2 stimulated Minute Ventilation(experimental)
- Reduction in BIS score(Experimental)
- Performance on Stroop test(Experimental)
研究者
研究点 (1)
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