Assessment of the Nutritional Status of Children and Adolescents With Malignancies Aged Between 0-18, Based on BMI Percentiles and Standard Deviation Scores, at Diagnosis, During Treatment, and During Two Years Follow-up
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 135
- 主要终点
- Change in nutritional status during follow-up
研究概览
简要总结
The main objective of this study was the assessment of the nutritional status of children and adolescents aged between 0-18 with malignancies based on BMI percentiles and standard deviation scores, at diagnosis, during treatment and during a period of two years after the end of therapy.
详细描述
Children and adolescents suffering from malignancies often show malnutrition. Malnutrition, defined as a deficiency or an excess of energy, is associated with an increased risk of comorbidities, reduced survival rates, higher relapse rates, and worse treatment response.
The present retrospective study assessed the nutritional status of children and adolescents, suffering from nine different kinds of cancer, based on BMI percentiles and standard deviation scores. Anthropometric data were recorded from clinical charts and an assessment of the nutritional status was made at the beginning of treatment, during the course of therapy and during a follow-up period of two years. The influence of treatment-related characteristics, the duration of therapy, and the occurrence of a relapse or progress during therapy on the nutritional status were examined.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children and adolescents treated at the Olgahospital Stuttgart for one of the nine different cancer types
- •treated according to a study protocol of the Society of Pediatric Oncology and Hematology (GPOH), with modifications only allowed within the therapeutic protocol
- •time period between diagnosis and start of treatment less than 28 days
- •age younger than 18
排除标准
- •severe underlying disease, which exerts a strong influence on weight and/or height
- •patients whose clinical record does not state any weight and/or height
- •diseases which are not considered as malignant because of the state or biology
结局指标
主要结局
Change in nutritional status during follow-up
时间窗: Once in a period of three months during two years follow-up
To assess the nutritional status height and weight were recorded from patient chart to calculate the BMI percentile and the BMI-SDS
Nutritional status at diagnosis
时间窗: Within the month of diagnosis
To assess the nutritional status height and weight were recorded from patient charts to calculate the BMI percentile (Body Mass Index percentile) and the BMI-SDS (Body Mass Index-Standard Deviation Score)
Change in nutritional status during treatment
时间窗: Every month during the treatment period (average treatment period 11 months)
To assess the nutritional status height and weight were recorded from patient charts to calculate the BMI percentile and the BMI-SDS
次要结局
- Constipation(Patients were followed for the occurence of constipation within the treatment period (average treatment period 11 months))
- Kind of treatment(Patients were followed for the kind of treatment they received wihin the treatment period (average treatment period 11 months))
- Age (years)(Within the month of diagnosis)
- Treatment period (months)(Patients were followed for the duration of their treatment period. Average treatment period 11 months)
- Fever(Patients were followed for the occurence of fever within the treatment period (average treatment period 11 months))
- Mucositis(Patients were followed for the occurence of mucositis within the treatment period (average treatment period 11 months))
- Incidence of nutritional interventions(Patients were followed for the incidence of a nutritional intervention within the treatment period (average treatment period 11 months))
- Infection(Patients were followed for the occurence of an infection within the treatment period (average treatment period 11 months))
- Administration of antibiotics(Patients were followed for the occurence of an administration of antibiotics within the treatment period (average treatment period 11 months))
- Diarrhea(Patients were followed for the occurence of diarrhea within the treatment period (average treatment period 11 months))
- Relapse/Progress(Patients were followed for the occurence of a relapse/progress within the treatment period (average treatment period 11 months) and follow-up (two years))
- Clinical picture(Within the month of diagnosis)
- Nausea(Patients were followed for the occurence of nausea within the treatment period (average treatment period 11 months))