Muscle Typology and Strength Training Adaptations
- Conditions
- Muscle Fiber TypeTraining FrequencyExercise
- Interventions
- Other: Muscle typology + exercise trainingOther: Muscle typology + training frequency
- Registration Number
- NCT05108181
- Lead Sponsor
- University Ghent
- Brief Summary
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.
Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Fast or slow muscle typology
- 18 - 45 years old
- no strength training experience
- Vegan/vegeterian diet
- Supplement intake
- chronic diseases
- Hypertension,
- Smoking
- Medication use
- Coagulation disorder, infectious diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fast muscle typology group Muscle typology + training frequency The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. Slow muscle typology group Muscle typology + exercise training The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. Slow muscle typology group Muscle typology + training frequency The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. Fast muscle typology group Muscle typology + exercise training The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.
- Primary Outcome Measures
Name Time Method Change from baseline isometric muscle strength at 9 weeks Pre and post 9 weeks training period Upper legs and upper arms - Biodex
Change from baseline dynamic muscle strength at 6 weeks Pre, mid and post 9 weeks training period Upper legs and upper arms - strength training devices
Change from baseline muscle volume at 9 weeks Pre and post the 9 weeks training period Muscle volume of the legs and the upper arms - MRI
Change from baseline dynamic muscle strength at 9 weeks Pre, mid and post 9 weeks training period Upper legs and upper arms - strength training devices
Change in muscle fiber type specific hypertrophy at 9 weeks Pre and post 9 weeks training period Legs - Biopsy (vastus lateralis)
Change from baseline dynamic muscle strength at 3 weeks Pre, mid and post 9 weeks training period Upper legs and upper arms - strength training devices
- Secondary Outcome Measures
Name Time Method Change of baseline antropometry at 9 weeks Pre and post 9 weeks training period Height, weight, skinfolds
Change of baseline skeletal muscle protein content at 9 weeks Pre and post 9 weeks training period Histochemistry and protein content of markers of relevance for skeletal muscle function
Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks Pre and post 9 weeks training period Fasted blood samples
Change of baseline histochemistry at 9 weeks Pre and post 9 weeks training period Histochemistry of markers of relevance for skeletal muscle function
Change from basline fatigue feeling over 9 weeks training period Assessed every training during the 9 weeks training period Number of repetitions during every training, questionnaire (VAS-scale) before every training, RPE after every training
Trial Locations
- Locations (1)
Department of Movement and Sports Sciences, Ghent University
🇧🇪Gent, Oost-Vlaanderen, Belgium