The Benefit of Autologous Blood Transfusion in Total Hip Arthroplasty
- Conditions
- TransfusionHip Arthroplasty
- Registration Number
- NCT04304287
- Lead Sponsor
- Clinical Hospital Centre Zagreb
- Brief Summary
The investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.
- Detailed Description
Total hip arthroplasty is procedure followed with large perioperative and postoperative blood loss. In order to avoid the application of large amounts of allogeneic blood, preoperative autologous blood donation as a tipe of autologous transfusion have been developed.
In this study, the investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.
Participants were divided into three groups: the first group donated one dose of autologous blood 14 days preoperatively, the second group donated one dose of autologous blood 72 hours preoperatively and a third group was not donated autologous blood.
The blood parameters, hemodynamic stability, bleeding, the need for application of autologous or homologous blood and length of hospital stay were compared.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- subject older than 18 years
- subject has primary coxarthrosis
- subject has indication for total hip replacement
- subject has secondary coxarthrosis
- subject has need for revision endoprosthesis
- history of autoimmune, malignancy or coagulation disorder
- history of myocardial infarct or cerebrovascular insult in last 6 months
- history of angina pectoris and unregulated hypertension
- history of renal or liver failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Patient red blood cells value 6 days analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day
Patient hematocrit value 6 days analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day
Need for autologous blood transfusion 6 days Based on blood count and hemodynamic stability
Need for homologous blood transfusion 6 days Based on blood count and hemodynamic stability
Patient hemoglobin value 6 days analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day
- Secondary Outcome Measures
Name Time Method Length of hospital stay 6 days measure of length of hospital stay