Evaluation of blood biomarkers for the identification of serious stroke

Not Applicable

• Conditions: Suspected acute stroke; Circulatory System; Stroke, not specified as haemorrhage or infarction

• Registration Number: ISRCTN60633358
• Lead Sponsor: orthumbria Healthcare NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-04-26
• Last Update Posted: 15 August 2022
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

1. Aged 18 years or over
2. Arrived at the study hospital by emergency ambulance
3. New acute stroke suspected by ambulance personnel before hospital arrival
4. At least responsive to tactile stimuli (i.e. A, V or P on the AVPU scale) on hospital arrival
5. New suspected stroke symptoms are still present when taking blood measurements
6. Blood sampling can be undertaken within 6 hours of suspected stroke symptom onset/last known well (times determined by hospital specialist staff)
7. Blood sampling can be undertaken prior to any reperfusion treatments
8. Routine brain imaging is intended to be urgently performed

Exclusion Criteria

1. Already assessed at another hospital and ambulance admission is a transfer for continuing care
2. Hypoglycaemia (capillary glucose <3.5 mmol/l)
3. External signs of significant acute trauma which are likely to need additional treatment (large haematomas, open wounds, limb deformity)
4. Assigned a recent previous (within the last 4 weeks) diagnosis likely to have resulted in elevated D-dimer levels i.e. deep vein thrombosis, pulmonary embolism, arterial embolism, stroke, long bone fracture, major trauma, any surgery under general anaesthesia
5. Chemotherapy or radiotherapy treatment for cancer within the last 7 days

Study & Design

• Study Type: Observational
• Study Design: Not specified