Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Cervicovaginal Fetal Fibronectin Level
研究概览
简要总结
Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester abortion.
详细描述
The population of the study will comprise 135 pregnant women attending Ain Shams University Maternity hospital at labor and delivery ward diagnosed with mid-trimester missed miscarriage confirmed by transabdominal ultrasound who will undergo termination by misoprostol.
Before entering the study, the purpose of this work will be clearly explained and verbal consent will be obtained from all patients enrolled in the study along with routine written informed consent as governed by the hospital rules.
All participants will be subjected to:
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History taking:
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Personal history: age and special habits
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Obstetric history (parity, history of abortions, previous cerculage and preterm labor). Gestational Age will be assigned by means of a combination of menstrual dating and ultrasonographic evaluation.
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Past medical history (hypersensitivity to misoprostol, chronic adrenal insufficiency and inherited porphyrias).
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Past history of previous cesarean section or other operations as hysterotomy and myomectomy.
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Examination:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Singleton pregnancy.
- •14-24 weeks gestation..
- •Missed miscarriage
排除标准
- •History of pulmonary, hepatic, renal, or cardiovascular diseases.
- •History of previous cesarean section and other uterine surgeries as hysterotomy and myomectomy.
- •Inevitable abortion.
- •Placenta covering internal os.
- •History of any cervical surgery as cervical amputation, cauterization or dilatation.
- •Premature rupture of membranes.
- •Any vaginal bleeding.
- •Contraindications for misoprostol as hypersensitivity to misoprostol, chronic adrenal insufficiency and inherited porphyrias.
结局指标
主要结局
Cervicovaginal Fetal Fibronectin Level
时间窗: 72 hours
mean cervicovaginal fetal fibronectin level in women undergoing midtrimesteric induction of abortion
Relation of Cervicovaginal Fetal Fibronectin Level to Duration of Induction of Abortion
时间窗: 72 hours
Difference between women who expulsed the fetus within 24 hours and women who expulsed the fetus in more than 24 hours as regarding cervicovaginal fetal fibronectin level (ng/ml)
次要结局
未报告次要终点
研究者
Amr Ahmed Mahmoud Riad
Lecturer of obstetrics and gynecology
Ain Shams Maternity Hospital