The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Marijuana Withdrawal
研究概览
简要总结
Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine whether a medication approved for treating insomnia can help restore normal sleep function during brief periods of abstinence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •current use of marijuana
- •able to give informed consent
排除标准
- •dependence on drug other than marijuana
- •current sleep disorder
- •pregnant, breast feeding, or planning to become pregnant within the next 3 months
- •currently seeking treatment for cannabis-related problems or otherwise trying to reduce use
- •use of cannabis under the guidance of a physician for a medical disorder
- •unstable or uncontrolled cardiovascular disease (e.g., hypertension, angina)
- •allergy to study medication
研究组 & 干预措施
Active Medication
Participants receive active hypnotic medication prior to sleep
干预措施: eszopiclone (Drug)
Active Medication
Participants receive active hypnotic medication prior to sleep
干预措施: ramelteon (Drug)
Active Medication
Participants receive active hypnotic medication prior to sleep
干预措施: zolpidem (Drug)
Placebo
Participants receive placebo prior to sleep
干预措施: Placebo (Drug)
结局指标
主要结局
Marijuana Withdrawal
时间窗: Every day during study participation
次要结局
- Objective Sleep Assessment(Every day during study participation)
- Cognitive Performance(Every day during study participation)
研究者
Ryan Vandrey
Associate Professor
Johns Hopkins University