Memory formation under stress in humans - the importance of the Mineralocorticoid Receptor - Memory & the MR

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 96 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- Male, healthy volunteers
•- Age 18 - 35 years
•- Normal or corrected-to-normal vision
•- Normal uncorrected hearing
•- Body mass index between 18.5 and 30
•- Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements

•- Acute or history of renal insufficiency / impairment of renal excretory function (or creatinine levels > 1.1 mg/dl at screening)
•- Hyperkalemia (or potassium levels of > 5.0 mEq/L at screening)
•- History of psychiatric treatment /current psychiatric treatment
•- History of neurological treatment /current neurological treatment
•- History of endocrine treatment /current endocrine treatment
•- History of autonomic failure (e.g., vasovagal reflex syncope)
•- History of psychotropic medication (e.g. antidepressants)
•- History of hepatic impairments
•- History of cardiovascular diseases
•- Hypotension (< 90 / 60 mmHG)
•- Bradycardia / Tachycardia (heart rate < 50 or > 100 at rest)
•- Use of any medication on a regular basis
•- Metal objects in or around the body
•- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel)
•- Claustrophobia
•- Use of recreational drugs weekly or more often
•- Smoking of more than 5 cigarettes per day
•- Average use of more than 3 alcoholic beverages daily and self-reported inability or un-ease to cease drinking alcohol for 24 hours prior to testing.
•- Caffeine consumption 3 hours before testing
•- Professional sports or participation in competitions (as Spironolacton can lead to a positive doping test)

发起方

niversitair Medisch Centrum Sint Radboud