CTRI/2025/04/084715尚未招募不适用
Utility of molecular over traditional diagnostic method in diagnosis and management of ventilator associated pneumonia caused by Gram negative bacteria in intensive care unit
Dr Avinash Agrawal1 个研究点 分布在 1 个国家目标入组 184 人开始时间: 2025年4月24日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 184
- 试验地点
- 1
- 主要终点
- To study the outcome 28 days mortality of early molecular identification of Gram negative organisms causing VAP and identification of common carbapenem resistant genes KPC IMP VIM NDM or OXA 48 compared with traditional culture methods
研究概览
简要总结
The study aims at evaluating the diagnostic performance of molecular based PCR compared to standard microbiological culture test
and the potential impact of its results on early modification of antimicrobial therapy along with clinical outcomes in ICU patients with clinically defined VAP.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •patients having clinically defined VAP according to CDC Age more than or equal to 18 years.
排除标准
- •Patients with evidence of chest infection prior to intubation or within 48 hours of mechanical ventilation Patients with severely immunocompromised state such as Acquired Immune Deficiency Syndrome organ transplant patients terminal stage of malignancy Patients whose sample could not be obtained Patients who are not willing to participate or give consent.
结局指标
主要结局
To study the outcome 28 days mortality of early molecular identification of Gram negative organisms causing VAP and identification of common carbapenem resistant genes KPC IMP VIM NDM or OXA 48 compared with traditional culture methods
时间窗: At baseline 4 weeks and 90 days
次要结局
- To compare the change in targeted antibiotic therapy selection according to molecular method and culture method(2 days)
- To compare the change in Clinical Pulmonary Infection Score on third day of management on the basis of molecular method and culture method(3 days)
- To compare the effect of diagnosis and management of VAP by both the methods on 90 days mortality(90 days)
研究者
Krishna Priya Agrawal
King Georges Medical University Lucknow
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Introduction of Polymerase Chain Reaction (PCR) in Microbiology and ParasitologyNCT07269314Fondazione IRCCS Policlinico San Matteo di Pavia200
尚未招募
不适用
Diagnostic PCR Panel in Children With Acute Gastrointestinal SymptomsNCT07280624University of Oulu526
招募中
4 期
Use of MULTIplex PCR, procalcitonin and the appearance of sputum to reduce the duration of antibiotic therapy during severe COPD EXAcerbation: a trial controlled, randomized, open, in parallel groups, multicenter2024-511896-13-00Assistance Publique Hopitaux De Paris204
已完成
不适用
Treatment Patterns and Key Endpoints Among Patients With Chronic-Phase Chronic Myeloid Leukemia in a Community Oncology SettingNCT07374120Novartis Pharmaceuticals1,480
尚未招募
4 期
Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated PneumoniaNCT07403474Centre Hospitalier Universitaire de Nīmes124