NCT01120769撤回不适用
Acetaminophen to Prevent Ischemic Oxidative Reperfusion Injury During Percutaneous Coronary Intervention for Acute Myocardial Infarction
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Plasma isoprostane level
研究概览
简要总结
The purpose of this study is to test the hypothesis that acetaminophen will reduce lipid peroxidation and isoprostane formation during reperfusion after percutaneous revascularization for acute myocardial infarction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients presenting with STEMI
排除标准
- •Duration of symptoms > 12 hours
- •Suspected LM or proximal LAD occlusion (based on EKG interpretation)
- •Hemodynamic instability
- •Acetaminophen use in prior 24 hours
- •Use of dipyridamole, or Aggrenox, a formulation of aspirin and extended-release dipyridamole, within 48 hours
- •Current use of the following medications: phenytoin, valproic acid, phenobarbital, topiramate, rifampin, carbamazepine, cyclophosphamide, ritonavir, efavirenz, St. John's Wort
- •Chronic heavy alcohol use
- •Chronic liver disease (other than non-alcoholic fatty liver infiltration)
- •Severe valvular heart disease
- •Stroke in the past 60 days
- •Active major bleeding
- •Major surgery in the past 30 days
- •Ongoing treatment for active malignancy
- •Life expectancy less than 12 months as determined by the patient's attending physician
- •Pregnancy
- •asthma or severe COPD
- •active wheezing on presentation
- •allergy or prior adverse reaction to adenosine
研究组 & 干预措施
Acetaminophen
Active Comparator
干预措施: Acetaminophen (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Plasma isoprostane level
时间窗: 60 minutes
次要结局
- Index of microcirculatory resistance(Average 20 minutes)
研究者
John Oates
Professor of Medicine
Vanderbilt University
研究点 (1)
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