The effect of lithium in the functional outcome of post ischemic stroke patients

Not Applicable

• Conditions: Condition 1: Ischemic stroke. Condition 2: The sequelae of Ischemic Stroke.; Cerebral infarction due to thrombosis of cerebral arteries; Sequelae of cerebral infarction

• Registration Number: IRCT2012072210361N1
• Lead Sponsor: Deputy of research, Ahvaz Jundishapur University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Age among 50 to 90;
Sufferer from ischemic stroke (ischemic cerebrovascular accident) including class 1, 4 or 5 of TOAST classification system (i.e. all subtypes of ischemic stroke except than embolic stroke with cardiac origin) in the territory of middle cerebral artery; Maximum time passed from stroke should be equal or less than 48 hours; Consent for participation in study (by patient or his/her first degree relative); No-participation in any other clinical trial; Non-menopause females should not be pregnant or lactating mother.
Exclusion criteria: Co-existence of intracerebral hemorrhage (subarachnoid or intraparenchymal) or hemorrhagic conversion during hospitalization; Severe loss of consciousness (score greater than 3 from 1b and 1c questions of NIHSS in the time of entering to the study); Wernicke aphasia (pure or as a part of constellation of other symptoms); Organ failures that may interfere with consumption of lithium, including:
Acute or chronic kidney disease (Cr> 1.2)
Acute or chronic heart failure (EF < 40% or JVP>9cm or history of orthopnea or nocturnal dyspnea)
Acute myocardial infarction (during past 3 months or current hospitalization)
Pulmonary edema
Respiratory distress that demands ventilator
Acute or chronic diarrhea that lead to significant dehydration (dryness of mucosal membrane, sunken eyes or Bun/Cr ratio >20)
History of thyroid dysfunction or abnormal TSH
Inevitable need to thiazide diuretics, potassium sparing diuretics or ACE inhibitors (but not ARB like Losartan) or calcium channel blockers or need to more than 80mg/day of furosemide); Inevitable need to NSAID except than Aspirin; Non-adherence to physiotherapy and ordered rehabilitation.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional outcome of stroke patients. Timepoint: in the 5th day of intervention and in the 30th day of intervention. Method of measurement: By using NIHSS and Barthel index score.

Secondary Outcome Measures

Name	Time	Method
Mortality rate in stroke patients. Timepoint: During 30 days of intervention. Method of measurement: Based on the number of died cases.