Effects of Danggui Buxue Tang on Blood Biochemical Parameters in Male Recreational Runners

Not Applicable

Completed

• Conditions: Sports Anemia; Inflammation; Oxidative Stress; Hemolysis; Fatigue; Iron Deficiency
• Interventions: Dietary Supplement: Danggui Buxue Tang; Other: Placebo

• Registration Number: NCT02996786
• Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Brief Summary

The aim of this study is to examine the beneficial effects of Danggui Buxue Tang on blood biochemical parameters in male recreational runners.

Detailed Description

1. Male recreational runners would be recruited by community websites or email. After completely introducing the study, the participants would be requested to sign informed consent.

2. The participants would perform maximal oxygen consumption test prior to the supplementation. The participants would be supplemented with either Danggui Buxue Tang or placebo for a week before performing the 13-km run. A total of 4 times blood collection (before supplementation, immediate after running, 1 day and 3 days after running) would be performed for evaluating the effect of Danggui Buxue Tang on blood biochemical parameters.

Study Timeline

• Study Start: 2016-10
• Status Verified: 2016-11
• Study First Submitted: 2016-12-11
• Study First Submitted QC: 2016-12-14
• Study First Posted: 2016-12-19
• Primary Completion: 2017-07
• Study Completion: 2017-07
• Last Update Submitted: 2018-04-18
• Last Update Posted: 2018-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 39

Inclusion Criteria

• The participants should have the experience finishing 10-km run but without the experience of attending a marathon run.

Exclusion Criteria

• Participants suffering from anemia (Hb <13 g/dL), taking usual supplements, medication, alcohol or not feeling comfortable.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Danggui Buxue Tang group	Danggui Buxue Tang	Danggui Buxue Tang group receive orally supplementation of 7.5 g/day of Danggui Buxue Tang for 10 days
Placebo group	Placebo	Placebo group receive orally supplementation of 7.5 g/day of placebo for 10 days

Primary Outcome Measures

Name	Time	Method
Iron status	Through study completion, an average of 1 year	Serum iron, ferritin, transferrin and hepcidin
Oxidative stress	Through study completion, an average of 1 year	Thiobarbituric acid reactive substances, superoxide dismutase, catalase, and glutathione peroxidase
Inflammatory response	Through study completion, an average of 1 year	High-sensitivity c-reactive protein, Tumor necrosis factor-alpha, and interleukin-6
Hematological parameters	Through study completion, an average of 1 year	Complete blood counts and serum haptoglobin and erythropoietin

Secondary Outcome Measures

Name	Time	Method
Running time	Through study completion, an average of 1 year	The completion time for a 13-km run

Trial Locations

Locations (1)

Kaohsiung Medical University; 🇨🇳 Kaohsiung, Taiwan