Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Chronic Neuropathic Pain: Retrospective Study on a Cohort of 149 Patients at Rennes University Hospital, From January 2014 to December 2015
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- Evaluation of the efficacy of rTMS in the treatment of chronic neuropathic pain in a short term
研究概览
简要总结
A retrospective, monocentric, observational, descriptive, open study of a cohort of 149 patients from January 2014 to December 2015
详细描述
Neuropathic pain is a public health problem because of its prevalence reaching nearly 7% of the general population and the effectiveness of current treatments often remains incomplete: only 30-40% of patients are relieved of 50% of their pain by a pharmacological approach.
As early as the 1990s, stimulation of the motor cortex by implanted electrodes made it possible to successfully treat certain chronic refractory neuropathic pain. In 1995 it was reported that the application of repeated shocks by transcranial magnetic stimulation of the motor cortex could induce an analgesic effect in a patient suffering from neuropathic pain.
This technique has proved its analgesic efficacy after an induction treatment over 5 days, in the context of chronic pain (neuropathic or fibromyalgia), but all the patients are not responders and there is currently, Of predictive criteria for response. It seems important to continue studies on this non-medicinal, non-invasive therapy with no significant adverse effects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient older than 18 years old with chronic neuropathic pain who are resistant to drug therapy for which treatment with rTMS is indicated between January 2014 and December 2015
排除标准
- •Patient less than 18 years old
- •Pregnant woman
- •Non-neuropathic pain
- •Pain <6 months
- •Unbalanced epilepsy
- •Patient with a contraindication for cerebral MRI (cochlear implant, ocular metallic foreign bodies, patient with a pacemaker, mechanical valve)
- •Psychiatric pathology
- •Person subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
结局指标
主要结局
Evaluation of the efficacy of rTMS in the treatment of chronic neuropathic pain in a short term
时间窗: Day 7
Improvement of pain symptoms by at least 30% on the numerical scale
Evaluation of the efficacy of rTMS in the treatment of chronic neuropathic pain in a short term (≤ 1 month)
时间窗: Month 1
Improvement of pain symptoms by at least 30% on the numerical scale
次要结局
- Evaluate the effectiveness of rTMS in the treatment of long-term chronic neuropathic pain (> 6 months)(Month 6)