The Role of Endogenous Antiangiogenic Factors in Gastric Cancer Progression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Relationship between antiangiogenic factor and tumor, node, metastasis
研究概览
简要总结
Endogenous antiangiogenic factors are related with gastric cancer progression.
详细描述
Gastric cancers have been known to secrete the proangiogenic cytokine VEGF in vitro and in vivo. Tumor VEGF expression is correlated with the severity of disease in patients with gastric cancer and some authors have suggested using circulating VEGF as a prognostic factor or tumor marker.In addition to producing proangiogenic cytokines, recent data demonstrate that tumors can produce antiangiogenic cytokine as well. It has been suggested that, in humans, the generation of antiangiogenic compounds in the presence of a primary tumor suppresses the growth of distant metastases. This phenomenon has been demonstrated in mice and in patients with clear cell renal cancer, breast cancer, and colorectal cancer. However, the presence of endogenous antiangiogenic cytokines in patients with gastric cancer has not been reported.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Histologic diagnosis of gastric adenocarcinoma
- •No other forms of cancer therapy, such as chemotherapy or radiotherapy for at least 3 weeks before the enrollment in study
- •Performance status of 0, 1, 2 on the ECOG criteria
- •ASA class I, II
- •Patient compliance that allow adequate follow up
- •Informed consent from patient or patient's relative.
排除标准
- •Second primary malignancy
- •EMR (Endoscopic mucosal resection) indication
- •Laparoscopic gastrectomy
- •Radiologic or clinical evidence of metastasis
结局指标
主要结局
Relationship between antiangiogenic factor and tumor, node, metastasis
时间窗: One year
次要结局
- Overall survival, treatment failure(5 years)
研究者
Jun Ho Lee
Staff Surgeon
National Cancer Center, Korea