Intra-arterial injection of donor mesenchymal stromal cells for treating refractory acute Graft-vs-Host disease after hemopoietic stem cell transplantatio
Phase 1
- Conditions
- refractory acute GVHD
- Registration Number
- JPRN-UMIN000000845
- Lead Sponsor
- Department of Hematology, The Tazuke Kofukai Medical Research Institute Kitano Hospital
- Brief Summary
Enrolled case:3 Bone marrow collection & MSC culture:3 Culture using with FCS:0 MSC administration:3(intra-arterial) Early side effects:0 CR:0 PR:1 NC:1 PD:1
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
Not provided
Exclusion Criteria
1.Positive for HIV Ab 2.Uncontrollable infection such as mucor, EBV-LPD, Gancyclovir-refractory CMV, measles. 3.severe psychiatric disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical response at 2 weeks after MSC therapy
- Secondary Outcome Measures
Name Time Method Clinical response at 4 weeks after MSC therapy Overall survival at 4 weeks after MSC therapy