A Retrospective Review of the Association of Baseline Characteristics of Male Patients Presented With Lower Urinary Tract and Long Term Clinical Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 246
- 试验地点
- 1
- 主要终点
- The overall prevalence of diabetes in male patients presented with lower urinary tract symptoms (LUTS)
研究概览
简要总结
Non-neurogenic male lower urinary tract symptom (LUTS) is one of the most common symptom presented in urological clinic. Male LUTS could be a result of a combination of many different conditions, including benign prostate hypertrophy, overactive bladder, diabetes, noctural polyuria, sleep apnoea etc. Also male LUTS has shown to have close relationship with metabolic and cardiovascular conditions. Because of the increasing evidences to suggest a close relationship of cardiovascular condition and metabolic problems and male LUTS, this is a study to retrospective review of the patients assessed in this urology clinic and have a more in-depth assessment of the relationship of the baseline characteristics of these medical conditions with the presenting symptoms, as well as the long term urological and overall clinical outcomes of these patients.
详细描述
This is a retrospective study.Male patients who presented with lower urinary tract symptom to our centre and assessed in the urology clinic from 2005 to 2019 would be enrolled to the study. This study will be conducted by observation; that is, data will be captured from medical records and central medical system (CMS), but patients will not be contacted. All the demographic and medical background, as well as investigations performed during the assessment including uroflowmetry, post-voiding residual, questionnaires, blood pressure, pulse, vascular assessment and blood result will be collected. Follow-up data including usage of medication, clinical outcomes (such as development of urinary retention, cardiovascular events, need of surgical intervention, mortality etc.) will be captured from the medical records.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 35 Years 至 90 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men aged between 35 and 90 years old with LUTS/nocturia and received assessment at urology centre.
排除标准
- •Men having history of prostatic surgery, prostate cancer, active urinary tract infection, aortic aneurysm, marked cardiac arrhythmia and severe peripheral vascular disease
结局指标
主要结局
The overall prevalence of diabetes in male patients presented with lower urinary tract symptoms (LUTS)
时间窗: Through study completion, an average of 2 years
It is assessed by medical record
The overall prevalence of dyslipidaemia in male patients presented with lower urinary tract symptoms (LUTS)
时间窗: Through study completion, an average of 2 years
It is assessed by medical record
The overall prevalence of adverse cardiovascular events (MACE) in male patients presented with lower urinary tract symptoms (LUTS)
时间窗: Through study completion, an average of 2 years
Major adverse cardiovascular events such as myocardial infraction, ischemic heart disease, heart failure, coronary angioplasty etc. in male patients with LUTS. It is assessed by medical record
次要结局
- Correlation between nocturia and Central arterial stiffness (CAS)(Baseline)
- Overall mortality(Through study completion, an average of 2 years)
- Incidence of acute retention of urine(Through study completion, an average of 2 years)
- Incidence of requirement of surgical intervention(Through study completion, an average of 2 years)
研究者
Chi Fai NG
Professor
Chinese University of Hong Kong