Interaction of hypoxia and atmospheric carbon dioxide on healthy adults in the aircraft environment

Not Applicable

• Conditions: - healthy adults

• Registration Number: DRKS00015820
• Lead Sponsor: DLR- Deutsches Zentrum für Luft- und Raumfahrt - Institut für Luft- und Raumfahrtmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-06
• Study Completion: 2019-07-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

healthy
- moderate physical activity / sports
- Presence of written consent

Exclusion Criteria

- not the German language powerful
- Rhinitis
- chronic or acute lung diseases
- Claustrophobia
- BMI > or equal to 30 or < 17
- any medication that influences the examination parameters
- Alcohol and / or drug addiction
- Above average caffeine intake (ie > 5 cups of coffee / black tea per day)
- smoker
- Pregnancy (early pregnancy test before each chamber exposure)
- Menopause
- no physical activity
- intensive training within 1 week before the trial day
- Disease with prolonged bed rest within 6 weeks before the trial day
any other condition which, in the opinion of the performing physicians, makes the subject unsuitable (e.g., the ability to enter the pressure chamber independently)
- no longer stay at altitudes over 1500 meters in the last 3 months
- no flight longer than 1.5 hours in the last 6 weeks
- no scuba diving within 3 months before the trial day
- no regular singing exercises or playing wind instruments

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of arterial blood oxygen saturation to verify that increased CO2 content of respiratory air under hypobaric conditions leads to an increase in blood oxygen saturation measured by:<br>- Pulse oximetry<br>- near-infrared spectroscopy (on head and thigh)<br>- Capillary blood gas analysis (determination of partial pressures of oxygen (pO2) and carbon dioxide (pCO2), bicarbonate, base deficit and pH).<br>During each test day, the test subjects are bled once before the test and then 6 times in each one-hour interval, from which all parameters.