Peritumoral Injection of Immature Dendritic Cels to Irradiated Metastases of Solid Tumors
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Complete evaluation of untreated lesions with physical examination and appropriate X-rays and/or scans will be performed four to six weeks after the last DC injection.
研究概览
简要总结
Melanoma is the main cause of death in patients with skin cancer. Once it has metastasized, this cancer has been shown to respond to chemotherapy only in rare cases. Immunotherapy represents an approach to treatment based on the immune response to cancer antigens.
The long-term objective of this study is to develop a therapeutic approach for the treatment of cancer in general, and melanoma in particular, based on immunotherapy, using a combination of local tumor irradiation followed by injection of immature dendritic cells (iDC).The treatment will be followed by the injection of interferon alpha, which we expect will induce activation of the iDC.
This trial is based on the hypothesis that local radiation, which causes destruction of the tumor, in combination with injection of the patient's own iDC and the activation of these cells with interferon alpha, will induce an effective immune response against the tumor. In order to test the suggested approach, we propose a 20-patients clinical trial that will evaluate the objective clinical and immunological response to the proposed treatment in patients with malignant melanoma and other solid tumors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any patient above age 18, with measurable metastatic melanoma or other solid tumor, with at least one tumor deposit that is easily accessible to peri-tumoral DC injection. The preferred location is subcutaneous or intradermal. Patients with additional metastatic sites will not be excluded. Patients should have an expected survival of greater than three months.
- •Patient must have received accepted standard treatment of his or her cancer:
- •for melanoma - DTIC -containing protocol ,unless unwilling. Previous treatment with IL-2 is not an excluding factor.
- •for breast cancer - adriamycin and cyclophosphamide, taxanes, and vinorelbine-containing protocols
- •for lung, renal and GIT cancers- one previous chemotherapy line
- •Serum creatinine of 2.0 mg/dl or less.
- •Total bilirubin 1.6 mg/dl or less, except for patients with Gilbert's Syndrome who must have a total bilirubin less than 3.0 mg/dl.
- •WBC 3000/mm3 or greater.
- •Platelet count 90,000 mm3 or greater.
- •Serum AST/ALT less then two times normal.
- •ECOG performance status of 0, 1 or
- •Patients of both genders must be willing to practice effective birth control during this trial.
- •Patient agreed to participate in the study and has signed a written informed consent.
排除标准
- •Patients will be excluded:
- •who are undergoing or have undergone in the past 3 weeks any other form of therapy except from surgery for their cancer.
- •have active systemic infections, coagulation disorders, autoimmune disease or other major medical illnesses of the cardiovascular or respiratory systems or any known immunodeficiency disease.
- •who require steroid therapy.
- •who are pregnant (because of possible side effects on the fetus).
- •who are known to be positive for hepatitis B and C or HIV antibody (because of possible immune effects of these conditions).
- •who have any form of primary or secondary immunodeficiency. (The experimental treatment being evaluated in this protocol depends on an intact immune system. Patients who have decreased immune competence may be less responsive to the experimental treatment and more susceptible to its toxicities.)
- •who are allergic to eggs.
- •i. who have an active major medical illnesses such as cardiac ischemia
结局指标
主要结局
Complete evaluation of untreated lesions with physical examination and appropriate X-rays and/or scans will be performed four to six weeks after the last DC injection.
Immunological evaluation will be performed two weeks after the last DC injection.
次要结局
未报告次要终点