Chronic Periodontitis and Polycystic Ovary Syndrome
- Conditions
- Polycystic Ovary SyndromeChronic Periodontitis
- Registration Number
- NCT02954120
- Lead Sponsor
- Bezmialem Vakif University
- Brief Summary
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals.
Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.
- Detailed Description
RESULTS:
Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P \< 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P \> 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P \< 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P \< 0.05). Salivary TAS levels were highest (P \< 0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (P \< 0.05).
CONCLUSIONS:
CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 88
- Newly diagnosed non-obese PCOS patients
- Never smokers
- Had no history of systemic disease
- BMI<25 kg/m2
- Participants had ≥20 teeth present.
- Pregnancy
- Lactation
- Hemoglobin A1c (HbA1c) ≥ 6.5%
- 2-h oral glucose tolerance test (OGTT-2h) ≥200
- Cushing syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid dysfunction, and androgen-secreting tumors
- Any drug use within the past 6 months
- Periodontal treatment within the past 6 months
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plaque Index (PI) appoximately 2 years Silnes-Löe Periodondal İndex
8-OHdG levels (nanogram per mililiter(ng/mL)) appoximately 2 years by ELISA test
Gingival Index (GI) appoximately 2 years Löe-Silness Periodontal Index
Bleeding on probing (BOP) appoximately 2 years Gİngival Bleeding Index
Probing pocket depth (PD)) appoximately 2 years distance between free gingival margin and periodontal pocket base by usin periodontal probe
Clinical attachment level (CAL) Patients were seen one time by measuring the distance between the cementoenamel junction and the periodontal pocket base
TAS levels (millimolar per liter (mmol /L)) appoximately 2 years by ELISA test
MDA levels (micromole per liter (µmol/L)) appoximately 2 years by ELISA test
- Secondary Outcome Measures
Name Time Method numberer of individuals with polycystic ovary syndrome appoximately 2 years individuals in the group
number of individuals with chronic periodontitis appoximately 2 years individuals in the group
Trial Locations
- Locations (1)
Department of Periodontics, Faculty of Dentistry, Bezmialem Vakif University
🇹🇷İstanbul, Fatih, Turkey
Department of Periodontics, Faculty of Dentistry, Bezmialem Vakif University🇹🇷İstanbul, Fatih, Turkey