Effect of Amlodipine on the Lipid Profile of Newly Diagnosed Hypertensive Patients

Phase 4

Completed

• Conditions: Cholesterol Deposition; Hypercholesterolemia; Hypertension
• Interventions: Drug: Amlodipine

• Registration Number: NCT05467384
• Lead Sponsor: Ayub Teaching Hospital

Brief Summary

In this study, Amlodipine has been used to study its effects in newly diagnosed hypertensive patients.

Detailed Description

The incidence of hypertension is on the rise in developing countries like Pakistan. Different medications are used to decrease blood pressure with Amlodipine as one of the first-line drugs. It was proposed that due to interaction with calcium and thus luminal cholecystokinin releasing factor; Amlodipine might increase the cholesterol level and thus cause dyslipidemia.

Objective: In this regard, this study was conducted to look into the effects of Amlodipine in newly diagnosed cases of hypertension that had received no medication previously.

Methodology: Experimental study with a healthy control group with the sample size calculated out to be 80, comprising of an equal number of enrolment into case and control groups.

Study Timeline

• Study Start: 2016-03-01
• Primary Completion: 2017-06-30
• Study Completion: 2017-06-30
• Study First Submitted: 2021-07-16
• Status Verified: 2022-07
• Study First Submitted QC: 2022-07-18
• Last Update Submitted: 2022-07-18
• Study First Posted: 2022-07-20
• Last Update Posted: 2022-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Newly Diagnosed Hypertensive patients	Amlodipine	These are the patients that have been clearly diagnosed with diabetes for the first time.

Primary Outcome Measures

Name	Time	Method
Measurement of Plasma High Density Lipoproteins Concentration	Four Months	Measured as per protocols provided by the kit manufacturer.
Measurement of Plasma Triglyceride Concentration	Four Months	Measured as per protocols provided by the kit manufacturer.
Measurement of Blood Glucose Concentration	Four Months	Measured as per protocols provided by the kit manufacturer.
Measurement of Total Plasma Cholesterol Concentration	Four Months	Measured as per protocols provided by the kit manufacturer.
Measurement of Plasma Low Density Lipoproteins Concentration	Four Months	Measured as per protocols provided by the kit manufacturer.