Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome

Not Applicable

Completed

• Conditions: Healthy Athletes

• Registration Number: NCT04444388
• Lead Sponsor: Universidad Europea de Madrid

Brief Summary

It has recently been suggested that cocoa may improve exercise performance and recovery. This study aim to evaluate the plasma and fecal metabolome after 10 weeks of cocoa supplementation during the training period in recreational athletes to detect possible metabolites involved in the observed benefits of cocoa in athletes

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-18
• Study First Submitted QC: 2020-06-20
• Study First Posted: 2020-06-23
• Study Start: 2020-07-01
• Primary Completion: 2020-10-01
• Study Completion: 2020-10-01
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-03
• Last Update Posted: 2020-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• 18-45 years of age
• high physical condition (VO2 ≥ 55 ml/kg/min)
• BMI 18-25 kg/m2

Exclusion Criteria

• antibiotics intake during 3 months prior to the study,
• smoking
• nutritional complements
• ergogenic complements
• prebiotics
• probiotics
• vegetarian or vegan diet
• chronic medication
• gastrointestinal surgery
• Any diagnosed disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Fecal metabolome profile	Changes from baseline to 10 weeks of intervention	Abundance of fecal metabolites, metabolic networks, and metabolic pathways determined by High Pressure Liquid Chromatography-Mass Spectrometry
Plasma metabolome profile	Changes from baseline to 10 weeks of intervention	Abundance of blood metabolites, metabolic networks, and metabolic pathways activity determined by High Pressure Liquid Chromatography-Mass Spectrometry
Fecal microbiota	Changes from baseline to 10 weeks of intervention	Abundance of bacterial taxa determined by 16SRNAr gene sequencing

Trial Locations

Locations (1)

Universidad Europea de Madrid; 🇪🇸 Villaviciosa de Odón, Madrid, Spain