Resilience and Brain Health of Older Adults (MEDEX-2)

Not Applicable

• Conditions: Age-related Cognitive Decline

• Registration Number: NCT05124132
• Lead Sponsor: Washington University School of Medicine

Brief Summary

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-16
• Study First Submitted: 2021-11-15
• Study First Submitted QC: 2021-11-15
• Study First Posted: 2021-11-17
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-13
• Last Update Posted: 2025-06-18
• Primary Completion: 2026-08-31
• Study Completion: 2026-08-31

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 468

Inclusion Criteria

• Participated in the parent study, Protocol ID #201410093

Exclusion Criteria

• Inability to safely continue classes or complete assessments, as per PI discretion

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Effects of the interventions on changes in cognitive performance	Approximately three years	Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites.

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States