Trigeminale Endonasale Perzeption, Ein Prädiktor für Das Outcome Einer Septumplastik - Eine Prospektive Kohortenstudie Mit Klinischen Und Biologischen Untersuchungen
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 140
- 试验地点
- 2
- 主要终点
- Measurement of subjective nasal breathing impairment after surgery depending on trigeminal perception threshold and TRP channel expression
研究概览
简要总结
This study investigates wether patients with increased trigeminal perception threshold and low expression of TRP channels have more often nasal blockage despite functionally successful nasal surgery (TRP channel = transient receptor potential channel).
详细描述
The aim of this study is to find out wether patients with high trigeminal perception threshold (=decreased intranasal sensibility) and low expression of TRP channels of the mucosa suffer more often from impaired nasal breathing after surgery. This could lead to the identification of prognostic factors and therefore prevention of nasal surgery with bad outcome.
Further, differences between patients with empty nose syndrome and asymptomatic patients after extended intranasal surgery, concerning trigeminal perception and TRP channel expression will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing a primary septoplasty and/or turbinoplasty
- •Patients suffering from empty nose syndrome after measurably successful nasal surgery
- •Patients with removed turbinates and/or septum, not suffering from ENS (i.e. tumor patients)
排除标准
- •Patients with known neurologic disorders that could compromise perception threshold measurements
- •Patients with known allergies/intolerance to test agents that are used to measure perception thresholds (Cineol=Eucalypt; Menthol, CO2= Carbon Dioxide)
- •Inability to judge or understand the testing or the informed consent
结局指标
主要结局
Measurement of subjective nasal breathing impairment after surgery depending on trigeminal perception threshold and TRP channel expression
时间窗: Up to 1 year post-surgery
次要结局
- Differences between trigeminal perception threshold as as well as TRP expression levels in patients with postoperative empty nose syndrome and patients with subjectively unimpaired nasal breathing after extended intranasal surgery(Up to 1 year post-op)