Diaphragm Ultrasound in Neuromuscular Disorders
- Conditions
- Muscular Dystrophies
- Registration Number
- NCT04045158
- Lead Sponsor
- Centre d'Investigation Clinique et Technologique 805
- Brief Summary
Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function.
The aims of the study are:
* to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies
* to assess the correlation between diaphragm ultrasound and FPT
* to assess the correlation between diaphragm ultrasound and cardiac function
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1000
- Duchenne muscular dystrophy,
- Becker muscular dystrophy,
- LGMD,
- myotonic dystrophy type 1 and type 2,
- metabolic myopathy,
- mitochondrial myopathy,
- FSHD1 and 2,
- myasthenia
- history of cardiac surgery
- history of thoracic surgery
- brain traumatism
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method diaphragm ultrasound motion 1 year using echography
- Secondary Outcome Measures
Name Time Method correlation between diaphragm motion (mm) and forced vital capacity(ml) 1 year using echography and FPT
correlation between diaphragm motion (mm) and inspiratory capacity (ml) 1 year using echography and FPT
diaphragm thickness (mm) 1 year using echography
correlation between diaphargm thickness and maximal inspiratory pressure (cmH20) 1 year using echography and FPT
Trial Locations
- Locations (1)
Hopital Raymond Poincare
🇫🇷Garches, France