Diaphragm Ultrasound in Neuromuscular Disorders

Centre d'Investigation Clinique et Technologique 8051 site in 1 country1,000 target enrollmentMay 15, 2019

ConditionsMuscular Dystrophies

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Muscular Dystrophies
Sponsor: Centre d'Investigation Clinique et Technologique 805
Enrollment: 1000
Locations: 1
Primary Endpoint: diaphragm ultrasound motion
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function.

The aims of the study are:

to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies
to assess the correlation between diaphragm ultrasound and FPT
to assess the correlation between diaphragm ultrasound and cardiac function

Registry

clinicaltrials.gov

Start Date

May 15, 2019

End Date

May 10, 2020

Last Updated

6 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Centre d'Investigation Clinique et Technologique 805

Responsible Party

Principal Investigator

Abdallah FAYSSOIL

MD PhD

Centre d'Investigation Clinique et Technologique 805

Eligibility Criteria

Inclusion Criteria

•Duchenne muscular dystrophy,
•Becker muscular dystrophy,
•myotonic dystrophy type 1 and type 2,
•metabolic myopathy,
•mitochondrial myopathy,
•FSHD1 and 2,
•myasthenia

Exclusion Criteria

•history of cardiac surgery
•history of thoracic surgery
•brain traumatism

Outcomes

Primary Outcomes

diaphragm ultrasound motion

Time Frame: 1 year

using echography

Secondary Outcomes

correlation between diaphragm motion (mm) and forced vital capacity(ml)(1 year)
correlation between diaphragm motion (mm) and inspiratory capacity (ml)(1 year)
diaphragm thickness (mm)(1 year)
correlation between diaphargm thickness and maximal inspiratory pressure (cmH20)(1 year)