NCT04045158Unknown不适用
Diaphragm Ultrasound in Neuromuscular Disorders
Centre d'Investigation Clinique et Technologique 8051 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2019年5月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- diaphragm ultrasound motion
研究概览
简要总结
Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function.
The aims of the study are:
- to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies
- to assess the correlation between diaphragm ultrasound and FPT
- to assess the correlation between diaphragm ultrasound and cardiac function
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Duchenne muscular dystrophy,
- •Becker muscular dystrophy,
- •myotonic dystrophy type 1 and type 2,
- •metabolic myopathy,
- •mitochondrial myopathy,
- •FSHD1 and 2,
- •myasthenia
排除标准
- •history of cardiac surgery
- •history of thoracic surgery
- •brain traumatism
结局指标
主要结局
diaphragm ultrasound motion
时间窗: 1 year
using echography
次要结局
- correlation between diaphragm motion (mm) and forced vital capacity(ml)(1 year)
- correlation between diaphragm motion (mm) and inspiratory capacity (ml)(1 year)
- diaphragm thickness (mm)(1 year)
- correlation between diaphargm thickness and maximal inspiratory pressure (cmH20)(1 year)
研究者
Abdallah FAYSSOIL
MD PhD
Centre d'Investigation Clinique et Technologique 805
研究点 (1)
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