Upper Body Subcutaneous Adipose Tissue Outflow Response to a Meal
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Adipose tissue blood flow
研究概览
简要总结
The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All women must be premenopausal
排除标准
- •Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
- •Diabetes, history of cardiovascular disease
- •Allergy to lidocaine
- •Post-menopausal women
研究组 & 干预措施
Obesity group
5 male and 5 female volunteers with obesity (BMI 29.0-35.0 kg/m2)
干预措施: Meal Study (Diagnostic Test)
Normal weight group
5 male and 5 female volunteers in normal weight range
干预措施: Meal Study (Diagnostic Test)
结局指标
主要结局
Adipose tissue blood flow
时间窗: 4 hours
Blood flow will be measured in the upper body subcutaneous adipose tissue using Xenon washout and reported as blood flow in ml/min/100g adipose tissue.
次要结局
- Glucose(Baseline, 4 hours)
研究者
Kelli A. Lytle
Principal Investigator
Mayo Clinic