Comparison of ketamine, dexmedetomidine, ketodex in prevention of emergence agitation in adults undergoing nasal surgery
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- To compare the level of emergence agitation in patients receiving ketamine, dexmedetomidine
研究概览
简要总结
Emergence agitation is a common side effect seen following nasal surgeries. Emergence agitation involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anaesthesia and can cause injury to patients and unwanted accidents in the operation theatre and post anaesthesia care unit. Various drugs have been used to decrease the incidence of emergence agitation following nasal surgeries.We are comparing the effects of three drugs ketamine, dexmedetomidine and a combination of ketamine and dexmedetomidine ie; ketodex which are routinely used to ameliorate or prevent emergence agitation, by comparison of recovery characteristics including extubation and Recovery time( Time in minutes from when inhalation agent is discontinued,to response to first verbal command);Level of agitation assessed by Riker Sedation Agitation Scale,level of painwill be assessed by Numeric pain rating scale;Hemodynamic parameters will be compared at regular intervals at post operative anaesthesia care unit;Post operative nausea vomiting will be assessed by 4 Point Post operative nausea and vomiting scale ;and Discharge time at arrival to post-anaesthesia care unite (PACU) to discharge to the ward according to modified Aldrete score, patients having Aldrete score of 9 or higher will be discharged to the ward.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of either sex scheduled for elective nasal surgeries under general anaesthesia -American society of Anesthesiologists physical status I,II.
排除标准
- •Patients with altered mental status Patients on psychoactive/analgesics/ Beta agonist drugs Pregnant women Patient with known allergy or hypersensitivity to the drugs used in the study Patients with anticipated difficult airway.
结局指标
主要结局
To compare the level of emergence agitation in patients receiving ketamine, dexmedetomidine
时间窗: Level of agitation assessed by Riker Sedation Agitation scale, At recovery & at admission to PACU. hemodynamic parameters, postoperative nausea vomiting and pain scores every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit
and ketodex atrecovery from general anaesthesia & admission to post anaesthesia care unit, Hemodynamic parameters, post operative nausea vomiting, pain score
时间窗: Level of agitation assessed by Riker Sedation Agitation scale, At recovery & at admission to PACU. hemodynamic parameters, postoperative nausea vomiting and pain scores every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit
次要结局
- Hemodynamic parameters(every 15 minutes till 30 minutes, followed by every 30 minutes for 2 hours at post operative anaesthesia care unit)
- Recovery time(Time in minutes from when sevoflurane is discontinued,to response to first verbal command)
- Level of pain(Will be assessed by Numeric pain rating scale at admission to postoperative anaesthesia care unit & at discharge from postoperative anaesthesia care unit.)
- Discharge time in minutes(The time from arrival to post-anaesthesia care unite (PACU) to discharge to the ward according to modified Aldrete score)
- Extubation time(Time from discontinuing sevoflurane to extubation.)
- Post operative nausea vomiting:(assessed by 4 Point Post operative nausea & vomiting scale at admission to post operative care unit and at discharge from post operative care unit)