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Clinical Trials/NCT06140706
NCT06140706
Not yet recruiting
Not Applicable

Feasibility of a Video Telehealth Model to Evaluate Home Use of Transcutaneous Spinal Cord Stimulation for Enhanced Upper Limb Function

VA Palo Alto Health Care System1 site in 1 country10 target enrollmentSeptember 1, 2025
ConditionsTetraplegia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Tetraplegia
Sponsor
VA Palo Alto Health Care System
Enrollment
10
Locations
1
Primary Endpoint
NASA-TLX (NASA Task Load Index)
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

The proposed study will focus on the feasibility of and effectiveness to a home-based program for persons with chronic SCI focused on upper limb training augmented with a transcutaneous neurostimulator supported via a video telehealth platform.

Detailed Description

The overarching goal of this study is to train participants with tetraplegia and their companion to operate a non-invasive surface applied neurostimulation unit (ONWARD, ARCex) while performing a prescriptive functional task based upper extremity home program for 2 months. Participants will be supported with video-telehealth to assist with any difficulties that may arise and to progress their upper extremity home program. Evaluations will assess the feasibility of this video telehealth supported model as measured by the ease of use of the technology (QUEST 2.0, NASA-TLX) as well as participants ability to attend and complete all the training visits. Changes in upper extremity physical function will be measured using validated clinical tools (GRASSP, CUE-Q, DASH, COPM) as well as detailed evaluation of upper extremity muscle activation from surface EMG and strength measurements of pinch and grasp. The primary outcome measure of this study is feasibility, and the secondary outcome measure is to capture changes in upper extremity performance.

Registry
clinicaltrials.gov
Start Date
September 1, 2025
End Date
December 31, 2027
Last Updated
last year
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Sponsor
VA Palo Alto Health Care System
Responsible Party
Principal Investigator
Principal Investigator

Beatrice Jenny Kiratli PhD

Research Health Scientist

VA Palo Alto Health Care System

Eligibility Criteria

Inclusion Criteria

  • All gender, any ethnicity
  • Cervical Spinal Cord Injury C2-8
  • American Spinal Injury Association (ASIA) Impairment Scale (AIS) B, C or D
  • GRASSP-Prehension Score \>10 or GRASSP Strength Score \>30
  • Greater than 1 year post injury
  • Able to identify a companion to assist with neurostimulator setup in home environment.
  • Internet connection to support video telehealth connection
  • Willingness to travel to the VA Palo Alto Medical Center

Exclusion Criteria

  • Cardiopulmonary disease or cardiac symptoms,
  • Autonomic dysreflexia that is uncontrolled or severe,
  • Implanted medical device(s),
  • Uncontrolled spasms that could limit participation in exercise training,
  • Skin breakdown or active pressure injury in areas of electrode placement.
  • Participants must not be engaged in any concurrent drug or device trial
  • Pregnant, are planning to become pregnant, or breastfeeding
  • The study is not deemed safe or appropriate in the opinion of the investigators

Outcomes

Primary Outcomes

NASA-TLX (NASA Task Load Index)

Time Frame: At 8 weeks (after completion of home program)

Measures subjective mental work load \& physical effort

QUEST 2.0 (Quebec User Evaluation of Satisfaction with assistive Technology)

Time Frame: At 8 weeks (after completion of home program)

Measures usability of device (eg, adjustability, comfort, safety and effectiveness)

Secondary Outcomes

  • CUE-Q (Capabilities of Upper Extremity Function)(At entry (Baseline) and repeated at 8 weeks (after completion of home program))
  • DASH (Disabilities of the Arm, Shoulder, and Hand)(At entry (Baseline) and repeated at 8 weeks (after completion of home program))
  • GRASSP (The Graded Redefined Assessment of Strength Sensibility and Prehension)(At entry (Baseline) and repeated at 8 weeks (after completion of home program))
  • COPM (Canadian Occupational Performance Measure)(At entry (Baseline) and repeated at 8 weeks (after completion of home program))

Study Sites (1)

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