A longitudinal study of patients with rheumatoid arthritis starting biological therapy; Assessment of joint inflammation by use of ultrasonography

Not Applicable

Completed

• Conditions: Arthritis in patients with rheumatoid arthritis; Synovitis and vascularization by use of ultrasonography including power Doppler; Inflammatory and Immune System - Rheumatoid arthritis; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12610000284066
• Lead Sponsor: Abbott Norge AS

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04-08
• Study Completion: 2015-08-01
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 296

Inclusion Criteria

Patients with rheumatoid arthritis
Clinical indication for starting biological treatment

Exclusion Criteria

Not prosthesis in more than 5 of the joints examined by ultrasonography.
Not enough knowledge of the Norwegian language to answer questionnaires.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess whether ultrasonographic examination of 36 joints and 4 tendons will be able to indicate responders to biological medication earlier than regular assessments (clinical and laboratory)[ Assessments at baseline and after 1, 2, 3, 6 and 12 months.]

Secondary Outcome Measures

Name	Time	Method
Degree of power Doppler activity at baseline and radiographic detorioration (hands and feet) after 12 months.[ Baseline power Doppler<br>12 months radiography];Associations between ultrasonographic findings and clinical as well as laboratory assessments.[ Baseline and at 1, 2, 3, 6 and 12 months]