Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training

Phase 3

Completed

• Conditions: COPD
• Interventions: Behavioral: Conventional resistance training program; Behavioral: Whole body vibration resistance training program

• Registration Number: NCT01135966
• Lead Sponsor: University Hospital, Ghent

Brief Summary

Pulmonary rehabilitation has been emerged as a recommended standard of care for patients with chronic lung disease based on a growing body of scientific evidence. A set of evidence-based guidelines were published in American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). Since then, the published literature in pulmonary rehabilitation has increased substantially, and other societies have published important statements about pulmonary rehabilitation (eg, the American Thoracic Society and the European Respiratory Society).

In patients with COPD, there is a strong scientific basis for implementing conventional resistance training (CRT) in addition to endurance training. Endurance training, such as walking, is a key component of pulmonary rehabilitation and improves in exercise tolerance and muscular endurance. However, this type of training may not reverse muscle weakness or atrophy. For that reason, strength training seems to be the optimum training modality to increase muscle mass and strength.

Recently, Whole-Body-Vibration (WBV) training has been promoted as an alternative for resistance training on multigym equipment. In WBV training, the subject stands on a platform that generates vertical sinusoidal vibration, during which static and dynamic exercises can be performed.

The present study is conducted to provide an answer on the following question: will a resistance training program, such as the whole body vibration, be even effective than a conventional resistance training program in patients with COPD.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2010-06-02
• Study First Submitted QC: 2010-06-02
• Study First Posted: 2010-06-03
• Primary Completion: 2011-07
• Study Completion: 2011-11
• Status Verified: 2011-12
• Last Update Submitted: 2011-12-09
• Last Update Posted: 2011-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Patients with COPD candidate for pulmonary rehabilitation
• Men and female between 40 and 80 years of age
• Written informed consent to participate

Exclusion Criteria

• Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise training.
• Pacemaker
• Hip, knee of shoulder prosthesis or recently introduced spirals, metal pens, bolts or plates
• Uncontrolled diabetes, epilepsy or migraine
• Osteoporotic or metastatic fractures, acute hernia, discopathy, spondylitis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conventional training	Conventional resistance training program	-
Whole body vibration training	Whole body vibration resistance training program	-

Primary Outcome Measures

Name	Time	Method
estimation of the change of 6 MWD before and after 12 weeks resistance training program (CRT versus WBV training)	before and after 12 weeks	estimation of the change of 6 MWD (submaximal walking test)after a 12 week conventional resistance training program or after a 12 week whole body vibration training program

Secondary Outcome Measures

Name	Time	Method
changes in Dyspnea scores after CRT or after WBV training in patients with COPD	before and after 12 weeks	measured by Chronic Respiratory Disease Questionnaire domain dyspnea (CRDQd) and by the BORG scale before and after 12 weeks of training.
changes in maximal exercise capacity after CRT or after WBV training in patients with COPD	before and after 12 weeks	measured by cyclo-ergospirometry before and after 12 weeks of training
changes in muscle strength (quadriceps force)after CRT or after WBV training in patients with COPD	before and after 12 weeks	measured by modified Microfet before and after 12 weeks of training.
changes in muscle force after CRT or after WBV training in patients with COPD	before and after 12 weeks	measured by handgrip force, maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax)before and after 12 weeks of training
changes in Quality of life after CRT or after WBV training in patients with COPD	beforer and after 12 weeks	measured by CRDQ (Chronic Respiratory Disease Questionnaire)before and after 12 weeks of training
changes in body composition after CRT or after WBV training in patients with COPD	before and after 12 weeks	measured by bioelectrical impedance analysis: Fat Free Mass (FFM)before and after 12 weeks of training.
changes in 6MWD and the endurance test on the bicycle after CRT or after WBV training in patients with COPD	before and after 12 weeks	measured by endurance test on the bicycle (75% Max. Workload)before and after 12 weeks of training. This test will also be repeated after 6 weeks of training.

Trial Locations

Locations (1)

University Hospital Ghent; 🇧🇪 Ghent, Belgium