To define the optimal glucose intake in critically ill childre

Completed

• Conditions: ernstig zieke kinderen met verschillende aandoeningen; nvt; 10010394; 10009720

• Registration Number: NL-OMON35471
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 64

Inclusion Criteria

-critically ill patients after elective surgery ( cardial, craniofacial of scoliosis surgery) admitted to the ICU
-critically ill patients with various medical diseases and > 1 organ failure admitted to the ICU.
- with arterial line
-inclusion 1 to 12 hours after admission
-cardiorespiratory stable
-only parental glucose after admission

Exclusion Criteria

endocrine disorders, liver failure, chromosomal disorders,
insulin therapy
no arterial line of after removal arterial line
no informed consent
in case of patient after elective cardiac surgery: no extracorporal circulation during cardiac surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-endogenous glucose production<br /><br>-fractional gluconeogenesis<br /><br>-glucose utilization<br /><br>-whole body protein balance.<br /><br>- fractional albumin synthesis rate.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>indirect calorimetry:determination of total energy expenditure<br /><br>urine samples for nitrogen excretion: protein utilization<br /><br>anthropometry</p><br>