Impact of Different Types of Physical Activity in Patients With Chronic Inflammatory Bowel Disease

Not Applicable

Completed

• Conditions: Inflammatory Bowel Diseases; Exercise Therapy
• Interventions: Other: Endurance training; Other: Resistance training

• Registration Number: NCT04589338
• Lead Sponsor: University of Liege

Brief Summary

This is a prospective interventional study. The investigators will include patients in clinical remission who are on stable treatment. These IBD patients will be followed to analyze the effects of physical activity on their inflammatory disease. Different exercises will be offered to two separate groups of randomly distributed patients: the first group will perform muscle building exercises while the other group will be offered aerobic exercises.There will also be a control group that does not initially benefit from a specific physical activity program. However, this group will be integrated into one of the other two groups after the 10-week follow-up. All three groups will perform the same baseline tests. These will be of different types: physical tests, biological tests and quality of life questionnaires.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-09-22
• Study First Submitted QC: 2020-10-13
• Study First Posted: 2020-10-19
• Study Start: 2021-01-05
• Primary Completion: 2022-12-15
• Study Completion: 2023-02-07
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-08
• Last Update Posted: 2023-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Patients in remission defined by a Harvey Bradshaw Index 5 in Crohn's disease (CD) and a clinical Mayo 3 with no sub-score >1 in ulcerative colitis (RCUH) with stable treatment, without corticosteroid for 4 months.
• Patients accepting the study protocol

Exclusion Criteria

• Patients suffering from other pathologies (at the level of the digestive system, the cardiovascular system, as well as the musculoskeletal system: recent knee plasty, recent knee fractures, etc.), which can interfere with planned tests and activity programs.
• Patients with more than 3 hours of sports activity per week
• Pregnant, pregnant or nursing patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Endurance training group	Endurance training	-
Resistance training group	Resistance training	-

Primary Outcome Measures

Name	Time	Method
Short health scale questionnaire	Week 20	Participants will complete a questionnaire to evaluate the level of the inflammatory bowel disease
EQ5D questionnaire	Week 20	Participants will complete a questionnaire on their level of health
Short Food Frequency Questionnaire	Week 20	Participants will complete a questionnaire on their dietary habits
Progressive effort test on bicycle ergometer (VO2 max)	through study completion, an average of 40 weeks	This test allows to measure VO2 in ml/min/kg (thanks to respiratory gases)
Progressive effort test on bicycle ergometer (Power)	through study completion, an average of 40 weeks	This test allows to measure maximum aerobic power in Watt.
Blood sample	through study completion, an average of 40 weeks	This type of tests includes biological monitoring to obtain information on biological parameters.
Saddle analysis	through study completion, an average of 40 weeks	This type of tests includes biological monitoring to obtain information on biological parameters.
IBD-F	Week 20	Participants will complete a questionnaire on fatigue perceived.
Progressive effort test on bicycle ergometer (Heart rate)	through study completion, an average of 40 weeks	This test allows to measure resting and maximum heart rate (thanks to an ECG) and maximum aerobic power in Watt.
Maximum force test (N/m)	through study completion, an average of 40 weeks	This test will be performed using an isokinetic dynamometer. This evaluation will allow us to determine the maximum force of the quadriceps and hamstrings of each participant in N/m.
Godin Leisure Time exercise questionnaire	Week 1	Participants will complete a questionnaire on the level of physical activity
Metabolic Equivalent Task questionnaire	Week 20	Participants will complete a questionnaire on the level of inactivity

Trial Locations

Locations (1)

Université de Liège; 🇧🇪 Liège, Belgium