Clinical Features and Outcome of Wilson's Disease With Generalized Epilepsy in Chinese Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Number of participants with treatment stop seizures attacks
研究概览
简要总结
Generalized epilepsy is rarely reported in patients with Wilson disease (WD) and lacks experience in clinical practice. We aim to provide better experience for the diagnosis and treatment for WD patients with epilepsy in the future.
详细描述
A retrospective study was performed in 13 Chinese WD patients with generalized epilepsy. Each patient was diagnosed with WD by clinical evaluation and genetic screening. Patients were given small doses of antiepileptic drugs (AEDs), followed by copper-chelation therapy when the seizures stabilized. Clinical manifestations, brain imaging changes, and treatment and outcome after a long-term follow-up were analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Each patient was diagnosed with WD by clinical evaluation and genetic screening and had ever experienced generalized epilepsy
排除标准
- •Not WD & without generalized epilepsy
结局指标
主要结局
Number of participants with treatment stop seizures attacks
时间窗: 12 month
After standard treatment, the patients would stop attacks and get improved.
次要结局
- Number of participants with treatment have improved brain MRI(12 month)