Comparing the Effect of High Flow Nasal Oxygen With Usual Care on Pulmonary Rehabilitation in COPD Patients After an Acute Exacerbation; a Pilot Randomized Controlled Trial

Changi General Hospital1 site in 1 country22 target enrollmentMay 28, 2019

ConditionsChronic Obstructive Pulmonary Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Chronic Obstructive Pulmonary Disease
Sponsor: Changi General Hospital
Enrollment: 22
Locations: 1
Primary Endpoint: 6-minute walk distance
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.

Detailed Description

This is a pilot randomized controlled trial to compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.

Registry

clinicaltrials.gov

Start Date

May 28, 2019

End Date

June 2021

Last Updated

5 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Changi General Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age 21 years and above
•Known diagnosis of COPD based on history AND spirometry demonstrating post bronchodilator FEV1/FVC ratio \<0.7
•Currently admitted inpatient for an acute COPD exacerbation as the primary diagnosis
•Fit to participate in exercise therapy as determined by both physician and physiotherapist
•Has the mental capacity to follow instructions
•Experience shortness of breath on exertion
•Have decreased ability to carry out activities due to shortness of breath
•Willing to participate in the exercise program

Exclusion Criteria

•Uncontrolled/ unstable medical conditions such as severe chronic heart failure that make exercise unsafe
•Pulmonary disorder other than COPD
•Physical conditions that preclude the ability to participate in exercise or may impair exercise performance.

Outcomes

Primary Outcomes

6-minute walk distance

Time Frame: 6 weeks

It is the maximum distance walked in 6 minutes

Secondary Outcomes

Hospital Anxiety Depression Scale(3 weeks, 6 weeks and 1 month after completion of program)
COPD Assessment Test score(3 weeks, 6 weeks and 1 month after completion of program)
Respiratory function test(3 weeks, 6 weeks and 1 month after completion of program)
6-minute walk distance(3 weeks and 1 month after completion of program)