Early and Late Prognosis in Patients With Guillain-Barre Syndrome
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- the severity of Guillain-barre syndrome
研究概览
简要总结
The goal of this observational study is to explore significant indicators to predict the early prognosis and late prognosis in patients with Guillain-Barre syndrome.
详细描述
This is a multicenter study(approximately three) with over 450 subjects.Clinical data were collected by consulting the patient's electronic history. The data included demographic information, blood biochemical markers, clinical characteristics and electromyography. All participants provided their written informed consent to participate in this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients fulfilled clinical, biological, and electrophysiology criteria for Guillain-barre syndrome.
排除标准
- •nonidiopathic Guillain-barre syndrome and Miller Fisher syndrome
研究组 & 干预措施
immunoglobulin group
This group of patients was treated with intravenous immunoglobulin(30g ivgtt qd) for 5 days
干预措施: Intravenous Immunoglobulins, Human (Drug)
methylprednisolone group
This group of patients was treated with methylprednisolone 500 MG Injection
干预措施: Methylprednisolone 500 MG Injection (Drug)
mixed group
This group of patients was treated both with intravenous immunoglobulin and methylprednisolone.
干预措施: Intravenous Immunoglobulins, Human (Drug)
mixed group
This group of patients was treated both with intravenous immunoglobulin and methylprednisolone.
干预措施: Methylprednisolone 500 MG Injection (Drug)
结局指标
主要结局
the severity of Guillain-barre syndrome
时间窗: baseline, at 1 week, at 26 weeks
The Guillain-barre syndrome disability score is a wide scale for the severity of Guillain-barre syndrome (0, optimal health; 1, minor symptoms, able to run; 2, able to walk unaided 10 m, unable to run; 3, able to walk 10 m across an open space with help; 4 bedridden or wheelchair users; 5, require assisted ventilation; 6, dead).The higher the score, the worse the prognosis.
次要结局
未报告次要终点