Registry of Multicenter Brain-Heart Comorbidity in China

Recruiting

• Conditions: Heart Failure; Ischemic Heart Disease; Aortic Diseases; Subarachnoid Hemorrhage; Occlusion and Stenosis of Cerebellar Arteries; Cardiac Arrest; Atrial Fibrillation; Cerebral Infarction; Occlusion and Stenosis of Precerebral Arteries; Moyamoya Disease

• Registration Number: NCT05961748
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. To establish a domestic multi-center, large-scale "brain-heart comorbidity" dynamic database platform including clinical, sample database, image and other multi-dimensional information requirements, through the construction of a multi-center intelligent scientific research integration platform based on artificial intelligence.

Any of newly diagnosed cardiovascular related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).

The data is stored on the brain-heart comorbidity warehouse via a physical server at the institution's data centre or a virtual hosted appliance. The brain-heart comorbidity platform comprises of a series of these appliances connected into a multicenter network. This network can broadcast queries to each appliance. Results are subsequently collected and aggregated. Once the data is sent to the network, it is mapped to a standard and controlled set of clinical terminologies and undergoes a data quality assessment including 'data cleaning' that rejects records which do not meet the brain-heart comorbidity quality standards. The brain-heart comorbidity warehouse performs internal and extensive data quality assessment with every refresh based on conformance, completeness, and plausibility (http://10.100.101.65:30080/login).

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-01
• Study First Submitted: 2023-07-07
• Study First Submitted QC: 2023-07-23
• Study First Posted: 2023-07-27
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-16
• Last Update Posted: 2023-09-21
• Primary Completion: 2032-12-31
• Study Completion: 2032-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100000

Inclusion Criteria

• age > 18 years old
• Any of newly diagnosed cardiovascular-related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) [i.e., ACS], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).

Exclusion Criteria

·refuse to participate in the registry

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of Participants with Composite of Cardiovascular Outcomes	At discharge/30 days	The occurrence of coronary artery disease event, stroke (ischemic or hemorrhagic), heart failure, or atrial fibrillation etc.
All-Cause Mortality	At discharge/30 days	The occurrence of death
Rate of Participants with Composite of All-Cause Mortality and Cardiovascular Outcomes	At discharge/30 days	The occurrence of all-cause mortality, coronary artery disease event, stroke (ischemic or hemorrhagic), heart failure, or atrial fibrillation etc.

Trial Locations

Locations (14)

Beijing Anzhen Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China

Beijing Tiantan Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China

Beijing Chaoyang Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China

Chinese People's Liberation Army (PLA) General Hospital; 🇨🇳 Beijing, Beijing, China

The First Affiliated Hospital of Harbin Medical University; 🇨🇳 Harbin, Heilongjiang, China

Xuanwu Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China

Shenzhen Qianhai Shekou Free Trade Zone Hospital; 🇨🇳 Shenzhen, Guangdong, China

The First Affiliated Hospital of Zhengzhou University; 🇨🇳 Zhengzhou, Henan, China

The First Affiliated Hospital of Fujian Medical University; 🇨🇳 Fuzhou, Fujian, China

The First Affiliated Hospital of Xiamen University; 🇨🇳 Xiamen, Fujian, China

Shanxi Provincial People's Hospital; 🇨🇳 Shanxi, Shanxi, China

The Second Affiliated Hospital of Kunming Medical University; 🇨🇳 Kunming, Yunnan, China

Huashan Hospital of Fudan University; 🇨🇳 Shanghai, Shanghai, China

Peking University First Hospital; 🇨🇳 Beijing, Beijing, China