Parkinson Progression Marker Initiative Online (PPMI Online)

Recruiting

• Conditions: Parkinson Disease

• Registration Number: NCT05065060
• Lead Sponsor: Michael J. Fox Foundation for Parkinson's Research

Brief Summary

Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk and predictive factors for PD.

PPMI Online is part of the broader Parkinson Progression Marker Initiative aimed at identifying markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

Detailed Description

PPMI is a broad program that is expanding the goals of the original PPMI study, and will include this PPMI Online protocol, as well the PPMI Clinical \[NCT04477785\], PPMI Remote, PPMI Digital protocols (with external regulatory oversight). All participants in PPMI may be asked to participate in one or all of these protocols and their enrollment in these studies may occur in varying order. PPMI participants may also be asked to participate in additional PPMI companion studies (as they are developed), which may only involve a subset of PPMI participants based on their cohort designation

Study Timeline

• Study Start: 2021-07-28
• Study First Submitted: 2021-09-02
• Study First Submitted QC: 2021-09-23
• Study First Posted: 2021-10-01
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-21
• Last Update Posted: 2024-11-25
• Primary Completion: 2041-12
• Study Completion: 2041-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500000

Inclusion Criteria

• Parkinson Disease (PD) Participants:

  • Male or female age 18 years or older.
  • Has received a diagnosis of Parkinson's disease

Participants without PD:

• Male or female age 18 years or older.
• Has not received a diagnosis of Parkinson's disease

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Unified Parkinson's Disease Rating Scale Ib & II	Baseline to 240 months	Evaluates self-reported motor and nonmotor Parkinson's disease symptoms

Trial Locations

Locations (1)

UCSF Movement Disorders and Neuromodulation Center (MDNC); 🇺🇸 San Francisco, California, United States