Validity of Sentinel Lymphnode Biopsy After Neoadjuvant Chemotherapy in Breast Cancer Patients With Radiologically Positive Axillary Lymph Nodes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
研究概览
简要总结
Sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) is currently debatable. It is possible that the tumor response to chemotherapy may alter the lymphatic drainage thus causing lower SLN identification rate and higher false negative rate. Further, the response of NAC can be different in each lymph nodes. It is doubtful whether SLNB can accurately predict axillary lymph node (ALN) status after NAC. The aim of this study to determine the identification rate, the false-negative rate, and the accuracy of SLNB after NAC for node positive breast cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Advanced breast cancer patients with node-positive proved in preoperative imaging study
- •ECOG status 0-1
排除标准
- •No previous cancer history
- •No previous chemotherapy history
研究组 & 干预措施
Clinically node-positive patients before NAC
Patients with clinically positive lymph node receiving neoadjuvant chemotherapy
- Clinically negative-node after NAC
- Clinically positive-node after NAC
干预措施: Sentinel lymph node biopsy (Procedure)
Clinically node-positive patients before NAC
Patients with clinically positive lymph node receiving neoadjuvant chemotherapy
- Clinically negative-node after NAC
- Clinically positive-node after NAC
干预措施: Neoadjuvant chemotherapy (Drug)
Clinically node-positive patients before NAC
Patients with clinically positive lymph node receiving neoadjuvant chemotherapy
- Clinically negative-node after NAC
- Clinically positive-node after NAC
干预措施: complete axillary lymph node dissection (Procedure)
Clinically node-positive patients before NAC
Patients with clinically positive lymph node receiving neoadjuvant chemotherapy
- Clinically negative-node after NAC
- Clinically positive-node after NAC
干预措施: positron emission tomography and ultrasonogram (Procedure)
研究者
Sung Gwe Ahn
Research Fellow, Breast Cancer Center
Gangnam Severance Hospital