Dietary Intake of Alpha-linolenic Acid in Elderly

Not Applicable

Completed

• Conditions: Cardiovascular Diseases; Inflammation; Metabolism Disorder, Lipid
• Interventions: Dietary Supplement: Sunflower oil; Dietary Supplement: Rapeseed oil

• Registration Number: NCT03025620
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The purpose of this study is to evaluate the antiatherogenic and anti-inflammatory potential of an adequate intake of alpha-linolenic acid in elderly.

Detailed Description

There is growing evidence that diets high in long chain n-3 polyunsaturated fatty acids (PUFA) decrease the risk of fatal ischemic heart disease.Both epidemiologic studies and clinical trials demonstrate substantial cardioprotective effects of alpha linolenic acid (ALA) from vegetable oils.However, little is known about the relation of the dietary intake of ALA with ischemic heart disease among older adults.In this study, elderly volunteers will be asked to ingest a supplement of a vegetable oil providing 1g of ALA, or an equivalent amount of linoleic acid as sunflower oil, for a diet period of 6 weeks.Serum samples will be collected before the dietary intervention and 6 weeks later.Plasma biomarkers of inflammatory, lipid cardiovascular risk factors and serum and red cell membrane fatty acid composition will be determined on all samples.

Study Timeline

• Study Start: 2006-11
• Primary Completion: 2011-02
• Study Completion: 2011-12
• Status Verified: 2017-01
• Study First Submitted: 2017-01-10
• Study First Submitted QC: 2017-01-18
• Last Update Submitted: 2017-01-18
• Study First Posted: 2017-01-19
• Last Update Posted: 2017-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 254

Inclusion Criteria

• Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease
• Male or female
• Subjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP)
• MMSE (Mini Mental State Examination)score > or = 15
• Supervision available for study medication
• Able to ingest oral diet

Exclusion Criteria

• Patients unable to understand the objectives of the dietary intervention
• Patients in paliative care
• Patients receiving supplement diets

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sunflower arm	Sunflower oil	Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of sunflower oil (with a high content in linoleic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with sunflower oil (60% fat) that replaced butter on the breakfast toasts.
Rapeseed arm	Rapeseed oil	Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of rapeseed oil (with a high content in alpha-linolenic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with rapeseed oil (60% fat) that replaced butter on the breakfast toasts.

Primary Outcome Measures

Name	Time	Method
Effects of diet supplementation on fatty acid composition in serum and red cell membrane phospholipids, at the end of dietary period	6 weeks	Blood samples have been done at the beginning and at the end of the dietary period. Fatty acids analyses of the red cells and serum have been performed by GC method.

Secondary Outcome Measures

Name	Time	Method
Others	6 weeks	ApoB ApoA1 Oxydative parameters (ie CRP) Lp(a)
Pulse wave velocity (PWV)	6 weeks	Pulse wave velocity values have been performed at the beginning and the end of the dietary period.; The purpose was to evaluate the relationship between PWV and dietary intakes of ALA.

Trial Locations

Locations (1)

hopital Emile Roux; 🇫🇷 Limeil Brevannes, France