Investigation of the Relationship Between Alpha-linolenic Acid and Arterial, Biochemical, Biological Parameters in Older Persons With History of Cardiovascular Events and/or Moderate Cognitive Impairment
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Diseases
- Sponsor
- Assistance Publique - Hôpitaux de Paris
- Enrollment
- 254
- Locations
- 1
- Primary Endpoint
- Effects of diet supplementation on fatty acid composition in serum and red cell membrane phospholipids, at the end of dietary period
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the antiatherogenic and anti-inflammatory potential of an adequate intake of alpha-linolenic acid in elderly.
Detailed Description
There is growing evidence that diets high in long chain n-3 polyunsaturated fatty acids (PUFA) decrease the risk of fatal ischemic heart disease.Both epidemiologic studies and clinical trials demonstrate substantial cardioprotective effects of alpha linolenic acid (ALA) from vegetable oils.However, little is known about the relation of the dietary intake of ALA with ischemic heart disease among older adults.In this study, elderly volunteers will be asked to ingest a supplement of a vegetable oil providing 1g of ALA, or an equivalent amount of linoleic acid as sunflower oil, for a diet period of 6 weeks.Serum samples will be collected before the dietary intervention and 6 weeks later.Plasma biomarkers of inflammatory, lipid cardiovascular risk factors and serum and red cell membrane fatty acid composition will be determined on all samples.
Investigators
Fathi Driss
Doctor
Assistance Publique - Hôpitaux de Paris
Eligibility Criteria
Inclusion Criteria
- •Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease
- •Male or female
- •Subjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP)
- •MMSE (Mini Mental State Examination)score \> or = 15
- •Supervision available for study medication
- •Able to ingest oral diet
Exclusion Criteria
- •Patients unable to understand the objectives of the dietary intervention
- •Patients in paliative care
- •Patients receiving supplement diets
Outcomes
Primary Outcomes
Effects of diet supplementation on fatty acid composition in serum and red cell membrane phospholipids, at the end of dietary period
Time Frame: 6 weeks
Blood samples have been done at the beginning and at the end of the dietary period. Fatty acids analyses of the red cells and serum have been performed by GC method.
Secondary Outcomes
- Others(6 weeks)
- Pulse wave velocity (PWV)(6 weeks)