Shanghai Mild Cognitive Impairment Cohort Study
Completed
- Conditions
- Mild Cognitive Impairment
- Registration Number
- NCT01552265
- Lead Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
- Brief Summary
This study was planned 1) to identify individuals with Mild Cognitive Impairment (MCI) who convert to Alzheimer's Disease (AD), and 2) to explore factors associated with the conversion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
- Cognitive concern reflecting a change in cognition reported by the patient or informant or clinician
- Mini-Mental State Examination (MMSE) scores between 18-30 (inclusive)
- Clinical Dementia Rating (CDR) =0.5; Memory Box score must be at least 0.5
- Objective memory loss* as evidenced by Auditory Verbal Learning test (AVLT-HS)
- Essentially preserved activities of daily living based on Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL)
- Not-demented, as defined by '"All-cause Dementia" (see 3.4. All-cause Dementia)
- Willing to and able to undergo all test procedures including neuroimaging, and agree to longitudinal follow up
- Written informed consent for the participation of this study including repeated neuropsychological tests and MRI scans
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to Conversion from MCI to "Probable AD Dementia" 3 years
- Secondary Outcome Measures
Name Time Method Changes in Neuropsychological examinations baseline, annual and 3 years Time to Conversion from MCI to "Possible AD Dementia" or "Probable AD Dementia" 3 years Overall survival 3 years Changes in MRI baseline, annual and 3 years Time to Conversion from MCI to "All-cause Dementia" 3 years
Trial Locations
- Locations (1)
Department of Neurology, Huashan Hospital, Fudan University
🇨🇳Shanghai, Shanghai, China