Prospective Evaluation of a Selection Protocol for Patients Over 70 Years Old for Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- 1 year patient survival
研究概览
简要总结
Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates typically have an age-associated burden of comorbid conditions that can pose several clinical challenges during the selection/evaluation process for LT. Specific algorithms for elderly patient selection for LT are not well established; however, consensus agreement is that elderly LT candidates need a more rigorous selection process.
This study proposes a "step by step" algorithm of selection for liver transplant candidates more than 70 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 71 Years 至 75 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >70 years and ≤ 75 years
- •Liver transplant from cadaveric donor
- •First liver transplant
- •End stage liver disease or liver tumor
排除标准
- •Age ≤ 70 years
- •Living donor liver transplant
- •Previous liver transplant
- •Liver transplant for acute liver failure
结局指标
主要结局
1 year patient survival
时间窗: 12 months
Overall patients survival at 12 months from liver transplantation
次要结局
- 1 year graft survival(12 months)
- 3 months mortality and morbidity(3 months)
研究者
Prof. Umberto Cillo
Director
Azienda Ospedaliera di Padova