Selection Protocol for Liver Transplantation in Patients Aged Over 70 Years

Recruiting

• Conditions: End Stage Liver DIsease; Old Age; Liver Transplantation

• Registration Number: NCT06382740
• Lead Sponsor: Azienda Ospedaliera di Padova

Brief Summary

Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates typically have an age-associated burden of comorbid conditions that can pose several clinical challenges during the selection/evaluation process for LT. Specific algorithms for elderly patient selection for LT are not well established; however, consensus agreement is that elderly LT candidates need a more rigorous selection process.

This study proposes a "step by step" algorithm of selection for liver transplant candidates more than 70 years.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-01
• Study First Submitted: 2023-03-09
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-22
• Last Update Submitted: 2024-04-22
• Study First Posted: 2024-04-24
• Last Update Posted: 2024-04-24
• Primary Completion: 2025-10-01
• Study Completion: 2025-10-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Age >70 years and ≤ 75 years
• Liver transplant from cadaveric donor
• First liver transplant
• End stage liver disease or liver tumor

Exclusion Criteria

• Age ≤ 70 years
• Living donor liver transplant
• Previous liver transplant
• Liver transplant for acute liver failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1 year patient survival	12 months	Overall patients survival at 12 months from liver transplantation

Secondary Outcome Measures

Name	Time	Method
1 year graft survival	12 months	Overall graft survival at 12 months from liver transplantation
3 months mortality and morbidity	3 months	Mortality and morbidity rates at 3 months from liver transplantation

Trial Locations

Locations (1)

U.O.C Chirurgia Epatobiliare e Trapianti Epatici, Azienda Ospedaliera di Padova; 🇮🇹 Padova, Italy