Prospective Evaluation of a Selection Protocol for Patients Over 70 Years Old for Liver Transplantation
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Azienda Ospedaliera di Padova
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- 1 year patient survival
Overview
Brief Summary
Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates typically have an age-associated burden of comorbid conditions that can pose several clinical challenges during the selection/evaluation process for LT. Specific algorithms for elderly patient selection for LT are not well established; however, consensus agreement is that elderly LT candidates need a more rigorous selection process.
This study proposes a "step by step" algorithm of selection for liver transplant candidates more than 70 years.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 71 Years to 75 Years (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age \>70 years and ≤ 75 years
- •Liver transplant from cadaveric donor
- •First liver transplant
- •End stage liver disease or liver tumor
Exclusion Criteria
- •Age ≤ 70 years
- •Living donor liver transplant
- •Previous liver transplant
- •Liver transplant for acute liver failure
Outcomes
Primary Outcomes
1 year patient survival
Time Frame: 12 months
Overall patients survival at 12 months from liver transplantation
Secondary Outcomes
- 1 year graft survival(12 months)
- 3 months mortality and morbidity(3 months)
Investigators
Prof. Umberto Cillo
Director
Azienda Ospedaliera di Padova