Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid

Not Applicable

Completed

• Conditions: Dental Implants
• Interventions: Other: Compoiste healing abutments; Other: Stock healing abutments

• Registration Number: NCT06034132
• Lead Sponsor: Alexandria University

Brief Summary

Numerous materials are nowadays used in the fabrication of healing abutments to be used for dental implants. soft tissue response to different healing abutment materials is still to be unraveled. the Aim of this study is to compare the soft tissue response to titanium stock healing abutments to customized composite healing abutments through assessing the level of matrix metalloproteinase-8 in the peri-implant crevicular fluid

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Primary Completion: 2023-06-15
• Study Completion: 2023-06-15
• Status Verified: 2023-09
• Study First Submitted: 2023-09-05
• Study First Submitted QC: 2023-09-05
• Last Update Submitted: 2023-09-05
• Study First Posted: 2023-09-13
• Last Update Posted: 2023-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with no systemic and/or oral health disease
• absence of any lesions in the oral cavity
• wide band of keratinized tissue more than 1mm at implant site

Exclusion Criteria

• smoking more than 20 cigarettes per day
• localized radiation therapy of the oral cavity,
• antitumor chemotherapy, liver diseases, blood diseases, kidney diseases, immunosuppressed patients, patients taking corticosteroids, pregnancy, inflammatory and autoimmune diseases of the oral cavity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Test group	Compoiste healing abutments	-
Control group	Stock healing abutments	-

Primary Outcome Measures

Name	Time	Method
Change in MMP8 levels	at 2 weeks and 4 weeks	Measuring MMP-8 level around composite and titanium healing abutments with ELISA kit

Secondary Outcome Measures

Name	Time	Method
Change in plaque accumulation	at 2 weeks and 4 weeks	Plaque index 0: No plaque is in the area adjacent to the gingiva. Plaque index 1: There is a plaque in the form of a thin film on the gingival margin.; Plaque index 2: There is a visible plaque in the gingival pocket and gingival margin.; Plaque index 3: There is a dense plaque in the gingival pocket and on the gingival margin.
Change in gingival condition	at 2 weeks and 4 weeks	Modified gingival index was used to assess gingival condition The MGI uses a rating score between 0 and 4 0 = absence of inflammation; 1. = mild inflammation; 2. = mild inflammation; 3. = moderate inflmmation; 4. = severe inflammation
Change in gingival bleeding	at 2 weeks and 4 weeks	Bleeding index will be recorded as present or absent

Trial Locations

Locations (1)

Alexandria Faculty of Dentistry; 🇪🇬 Alexandria, Egypt