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Clinical Trials/NCT06034132
NCT06034132
Completed
Not Applicable

Effect of Two Different Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid (a Randomised Clinical Trial)

Alexandria University1 site in 1 country30 target enrollmentJanuary 1, 2023
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ConditionsDental Implants

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Dental Implants
Sponsor
Alexandria University
Enrollment
30
Locations
1
Primary Endpoint
Change in MMP8 levels
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Numerous materials are nowadays used in the fabrication of healing abutments to be used for dental implants. soft tissue response to different healing abutment materials is still to be unraveled. the Aim of this study is to compare the soft tissue response to titanium stock healing abutments to customized composite healing abutments through assessing the level of matrix metalloproteinase-8 in the peri-implant crevicular fluid

Registry
clinicaltrials.gov
Start Date
January 1, 2023
End Date
June 15, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Hams Hamed Abdelrahman

Assistant lecturer of DPH and Clinical statistician

Alexandria University

Eligibility Criteria

Inclusion Criteria

  • •Patients with no systemic and/or oral health disease
  • •absence of any lesions in the oral cavity
  • •wide band of keratinized tissue more than 1mm at implant site

Exclusion Criteria

  • •smoking more than 20 cigarettes per day
  • •localized radiation therapy of the oral cavity,
  • •antitumor chemotherapy, liver diseases, blood diseases, kidney diseases, immunosuppressed patients, patients taking corticosteroids, pregnancy, inflammatory and autoimmune diseases of the oral cavity

Outcomes

Primary Outcomes

Change in MMP8 levels

Time Frame: at 2 weeks and 4 weeks

Measuring MMP-8 level around composite and titanium healing abutments with ELISA kit

Secondary Outcomes

  • Change in plaque accumulation(at 2 weeks and 4 weeks)
  • Change in gingival condition(at 2 weeks and 4 weeks)
  • Change in gingival bleeding(at 2 weeks and 4 weeks)

Study Sites (1)

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