Neurophysiological Biomarkers of Behavioral Dimensions From Cross-species Paradigms
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Motivation Signal
研究概览
简要总结
The effects of modafinil on measures of brain electrical activity will be tested.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
University of California, San Diego Experimental Pharmacy randomizes dose order and provides masked pills
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
modafinil 100 mg
Drug: modafinil, Provigil, Alertec, Modavigil
Dosage form, frequency and duration: Each participant receives a single pill of placebo or active drug (modafinil 100 mg or 200 mg) 30 minutes after arriving at the lab. The participant then completes approximately 6 hours of testing in the laboratory. The participant stays at the lab for 7.5 hours in order to monitor physical condition in case the participant received the active pill. One week later, that participant receives a single pill of an alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and two active pills, each time separated by one week.
干预措施: Modafinil (Drug)
modafinil 200 mg
Drug: modafinil, Provigil, Alertec, Modavigil
Dosage form, frequency and duration: Each participant receives a single pill of placebo or active drug (modafinil 100 mg or 200 mg) 30 minutes after arriving at the lab. The participant then completes approximately 6 hours of testing in the laboratory. The participant stays at the lab for 7.5 hours in order to monitor physical condition in case the participant received the active pill. One week later, that participant receives a single pill of an alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and two active pills, each time separated by one week.
干预措施: Modafinil (Drug)
placebo
Drug: modafinil, Provigil, Alertec, Modavigil
Dosage form, frequency and duration: Each participant receives a single pill of placebo or active drug (modafinil 100 mg or 200 mg) 30 minutes after arriving at the lab. The participant then completes approximately 6 hours of testing in the laboratory. The participant stays at the lab for 7.5 hours in order to monitor physical condition in case the participant received the active pill. One week later, that participant receives a single pill of an alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and two active pills, each time separated by one week.
干预措施: placebo (Drug)
结局指标
主要结局
Motivation Signal
时间窗: 1 year
Parietal EEG alpha power peak in first - final step toward breakpoint
Reward Positivity
时间窗: 1 year
Frontal alpha power by block in the probabilistic learning task
次要结局
未报告次要终点
研究者
Jared W. Young
Principal Investigator
University of California, San Diego