The Improvement of Black Raspberry in Obese and Mild AZ Patients Infected With H. Pylori
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Glycemic indices
研究概览
简要总结
The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori). Through checking various parameters including anthropometric, antioxidants, and CDR.
详细描述
The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori).
Preclinical studies (In vitro model) were conducted using 3T3-L1 adipocyte cells to check the anti-adhesion activity of BR.
For the clinical trial, a total of 21 obese mild AZ patients were recruited and separated into 2 groups: Experimental (BR group) and Placebo group.
Experimental group and Placebo group subjects were requested to take either 50 g of BR or 50 g of dextrin respectively for 4 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI ≧ 27, Waist circumference: men ≧ 90cm, women ≧ 80cm,
- •Body fat: male ≧ 25%, female ≧ 30%,
- •UBT 13C test value> 10‰ (H. pylori (+)),
- •CDR (clinical dementia rating) = 0.5
排除标准
- •Severe chronic diseases (liver disease, cardiovascular disease, kidney disease)
- •Alcohol abuse
- •Smoking habit
- •Taking berry-related supplementation or any known allergies related to berries.
- •Subjects with prior history of H. pylori infection were treated with triple therapy.
研究组 & 干预措施
Placebo group
Placebo group AZ subjects were requested to take 50 g of dextrin powder dissolved in 240 ml of water for 4 weeks.
干预措施: Placebo (Other)
BR group
Experimental group AZ subjects were requested to take 50 g of BR powder dissolved in 240 ml of water for 4 weeks.
干预措施: Black raspberry (Dietary Supplement)
结局指标
主要结局
Glycemic indices
时间窗: 8 weeks
No significant changes in any of the glycemic indices
Anthropometric parameters
时间窗: 8 weeks
BMI were significantly altered
次要结局
未报告次要终点
研究者
Chin Kun Wang
Professor
Chung Shan Medical University