NCT02394418
Withdrawn
Phase 4
Comparison of Sedative Effects of Sevoflurane, Propofol and Dexmedetomidine on the Clinical Course of Delirium and Neuroinflammation in Mechanically Ventilated Patients
Moscow Regional Research and Clinical Institute (MONIKI)0 sitesSeptember 1, 2017
ConditionsDelirium
Overview
- Phase
- Phase 4
- Intervention
- Sevoflurane
- Conditions
- Delirium
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
- Primary Endpoint
- Duration of Delirium
- Status
- Withdrawn
- Last Updated
- 6 years ago
Overview
Brief Summary
Assessment of sedative effects of sevoflurane, dexmedetomidine and propofol on the clinical course of delirium, SIRS and neuroinflammation in mechanically ventilated patients using CAM-ICU scale, GSK-3beta and protein S100b in serum.
Investigators
Valery V. Likhvantsev, Professor
senior researcher
Moscow Regional Research and Clinical Institute (MONIKI)
Eligibility Criteria
Inclusion Criteria
- •presence of delirium
Exclusion Criteria
- •presence of Alzheimer's disease
- •any mental disorder
- •presence of cancer
Arms & Interventions
Sevoflurane
Treatment of delirium by inhaled sevoflurane
Intervention: Sevoflurane
Propofol
Treatment of delirium by propofol i.v. infusion
Intervention: Propofol
Dexmedetomidine
Treatment of delirium by dexmedetomidine i.v. infusion
Intervention: Dexmedetomidine
Outcomes
Primary Outcomes
Duration of Delirium
Time Frame: up to 5 days
Delirium assessment by CAM-ICU scale
Secondary Outcomes
- Change of protein S100b in serum(from delirium onset up to 5 days)
- Change of GSK-3beta in serum(from delirium onset up to 5 days)
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