Genome wide association study on remission of asthma

Completed

• Conditions: asthma; 10006436

• Registration Number: NL-OMON36808
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 119

Inclusion Criteria

1. Age 18 years or older.
2. Previous diagnosis of asthma
3. Included in the GWA-study on asthma ;Additional inclusion criteria for the performance of spirometry and a histamine provocation test:
4. No current asthma symptoms
5. No use of asthma medication

Exclusion Criteria

1. Presence of serious concomittant diseases
2. Pregnancy
Additional exclusion criterium for histamine provocation testing:
3. FEV1 lower than 1.2 L

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Presence of complete asthma remission: no current asthma symptoms (asthma<br /><br>attacks, wheeze), no current use of asthma medication, FEV1 pre bronchodilator<br /><br>> 80% predicted, no bronchial hyperresponsiveness (PC20 histamine > 32 mg/ml).<br /><br>Associations between the single nucleotide polymorphisms genotyped in the GWA<br /><br>study and the presence of complete asthma remission will be studied using<br /><br>logistic regression analysis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>