Serum Levels of Angiotensin Converting Enzyme in Systemic Lupus Erythematous Patients

Not yet recruiting

• Conditions: Systemic Lupus Erythematosus
• Interventions: Diagnostic Test: Angiotensin Converting Enzyme test

• Registration Number: NCT05516511
• Lead Sponsor: Sohag University

Brief Summary

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that involve many different organs and display a variable clinical course.The prevalence of SLE varies across gender, race/ethnicity, and geographic regions. SLE demonstrates a striking female predominance with a peak incidence of disease during the reproductive years. In adults, the female to male ratio is 10- Renal involvement is common in SLE and is a significant cause of morbidity and mortality. It is estimated that as many as 90% of patients with SLE will have pathologic evidence of renal involvement on biopsy, but clinically significant nephritis will develop in only 50%. AII is a potent pro-inflammatory modulator with the ability to augment the immune responses in renal and non-renal tissues. Specifically in the kidney, AII stimulates mononuclear cells, favoring hyperplasia and hypertrophy of mesangial, tubular cells and interstitial fibroblasts, and increases expression and synthesis of the extracellular protein matrix leading to fibrosis.

Angiotensin II and strong candidate for a mediator of the development and progression of renal disease in SLE has been found to promote glomerular cell proliferation, alter growth factor expression, and activate proinflammatory cytokines, all of which promote glomerulosclerosis

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study First Submitted: 2022-08-24
• Study First Submitted QC: 2022-08-24
• Study First Posted: 2022-08-25
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-04
• Last Update Posted: 2022-11-09
• Study Start: 2023-01
• Primary Completion: 2023-03
• Study Completion: 2023-03

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• 1-Patients who fulfill the 2019 American College of Rheumatology/European League against Rheumatism classification criteria of Systemic Lupus Erythematosus 2-Patients diagnosed as lupus nephritis , actually did renal biobsy 3-Patients who is able to give informed consent to join the study

Read More

Exclusion Criteria

• • Any patient with any collagen disease other than systemic lupus erythematosus.

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cases	Angiotensin Converting Enzyme test	systemic lupus erythematosus patients
control	Angiotensin Converting Enzyme test	healthy individuals

Primary Outcome Measures

Name	Time	Method
serum creatine test	3 months	lab test , to asses renal function
protein creatine ratio	3 months	laboratory test, urine sample used to measure amount of proteinurea
Angiotensin Converting Enzyme test	3 months	laboratory test, ELISA kits, measure serum levels of angiotensin converting enzyme in SLE patients , control

Secondary Outcome Measures

Name	Time	Method
anti ds-DNA test	3 months	lab test , for diagnosis of SLE , lupus nephritis
Anti nuclear Anti body tset	3 months	lab tset, IF technique, for diagnosis of SLE disease

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt