A comparative study of two pain relief techniques - An injection at the back with morphine(drug for pain relief) versus an abdominal wall injection for donor nephrectomy(donor kidney removal) surgeries
Phase 2
Completed
- Registration Number
- CTRI/2016/07/007110
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. Consenting voluntary kidney donors scheduled for laparoscopic donor nephrectomy
2. Understanding spoken English/ Hindi
3. Controlled co-morbid conditions (ASA I-II)
Exclusion Criteria
1. Refusal to participate
2. Pre-existing neuropathy
3. Morbid obesity
4. Contra indication to performance of spinal block, eg: local infection
5. Inability to understand spoken English/Hindi
6. Incapable of handling a PCA device
7. Known allergy to any of the study drugs
8. History of severe PONV or motion sickness
9. History of chronic analgesic use
10.Uncontrolled systemic disease
11.Symptomatic cardiac/respiratory disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the efficacy of TAP block and intra-thecal morphine (ITM) for peri-operative analgesia in patients undergoing laparoscopic live donor nephrectomy compared to conventional analgesia by: 1. Peri operative fentanyl consumption <br/ ><br>2. VAS scores at rest and on movement. <br/ ><br>Timepoint: 0,2,4,6,12 and 24 hours time points
- Secondary Outcome Measures
Name Time Method 1. To assess the effect of intra-thecal morphine and TAP block on recovery characteristics: a. Time to Readiness for discharge from PACU b. Time to ambulate c. Time to oral intake <br/ ><br>2. To determine the incidence of adverse effects in all analgesic modalities: a. Respiratory depression b. Pruritus <br/ ><br>c. Nausea and vomiting (PONV) d. Catheter-related bladder discomfort (CRBD) <br/ ><br>Timepoint: TIME SCALES AS MINIMUM AS POSSIBLE